ArticleInfection and immunity2002
Antigenic diversity in Eimeria maxima and the influence of host genetics and immunization schedule on cross-protective immunity.
Article in Infection and immunity, 2002. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
28 citing papers in PubMed, 77 citations in OpenAlex.
- Review on anticoccidial vaccine development for chickens: Past progress, modern methods, and production bottlenecks.Poultry science · 2026Review
- Nanotechnology-Enabled Approaches in Poultry Coccidiosis Management: Advances, Challenges, and Future Perspectives.Poultry science · 2026Review
- Genetic diversity inVeterinary world · 2026Review
- Intraspecific Variations in Biology and Pathogenesis of Two Eimeria maxima Isolates From Distinct Geographic Locations.Veterinary medicine and science · 2025Article
- Isolation of a Novel CaprineAnimals : an open access journal from MDPI · 2025Article
- Study of dense granule proteins inFrontiers in immunology · 2025Article
- Comparative Analysis of Cross-Protective Immunity Among Three Geographically Distinct Isolates ofAnimals : an open access journal from MDPI · 2024Article
- A Study of Cross-Protection betweenPathogens (Basel, Switzerland) · 2024Article
- Epidemiological investigation of coccidiosis and associated risk factors in broiler chickens immunized with live anticoccidial vaccines in China.Frontiers in veterinary science · 2024Article
- RNA-Seq of Phenotypically DistinctPathogens (Basel, Switzerland) · 2023Article
- Genetic and biological characterisation of three cryptic Eimeria operational taxonomic units that infect chickens (Gallus gallus domesticus).International journal for parasitology · 2021Article
- Impact ofFrontiers in veterinary science · 2021Article
- Kinetics of the Cellular and Transcriptomic Response toFrontiers in immunology · 2021Article
- ExploringGenes · 2020Review
- Poultry Coccidiosis: Design and Interpretation of Vaccine Studies.Frontiers in veterinary science · 2020Review
- Parasitic nematodes simultaneously suppress and benefit from coccidian coinfection in their natural mouse host.Parasitology · 2019Article
- A review of Eimeria antigen identification for the development of novel anticoccidial vaccines.Parasitology research · 2019Review
- Diagnosis and control of chicken coccidiosis: a recent update.Journal of parasitic diseases : official organ of the Indian Society for Parasitology · 2018Review
- Dissecting the Genomic Architecture of Resistance toFrontiers in genetics · 2018Article
- EVALUATION OF THE ANTIGENICITY AND IMMUNOGENICITY OFAfrican journal of infectious diseases · 2018Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Eimeria spp. are a group of highly successful intracellular protozoan parasites that develop within enterocytes. Eimeria maxima from the chicken is characterized by high immunogenicity (a small priming infection gives complete immunity to subsequent homologous challenge) and naturally occurring antigenically variant populations that do not completely cross-protect. In this study we examined the expression of antigenic diversity in E. maxima, as manifested by cross-strain protection in a series of inbred chicken lines. The IAH line of Light Sussex chickens and all lines of inbred White Leghorns were susceptible to primary infections with either of two strains (H and W) of E. maxima and were protected completely against challenge with the homologous strain of parasite. The extent of cross-protection against the heterologous parasite strain varied from 0 to almost 100% depending on host genetics. Interestingly, in one inbred line of chickens (line 15I) the cross-protective phenotype was directional and intensely influenced by the infection history of the host. The basis for the observed variation in cross-protection is not known, but our results suggest that the major histocompatibility complex is not a major genetic component of the phenotype. These results are discussed in relation to the number of protective antigens presented by complex pathogens and the development of immunoprotective responses in hosts of different genetic backgrounds.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.