ArticleInfection and immunity2002
Novel Aeromonas hydrophila PPD134/91 genes involved in O-antigen and capsule biosynthesis.
Article in Infection and immunity, 2002. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 24 papers.
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24 citing papers in PubMed, 43 citations in OpenAlex.
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- Identifying genetic diversity of O antigens in Aeromonas hydrophila for molecular serotype detection.PloS one · 2018Article
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- Classification of a HypervirulentFrontiers in microbiology · 2016Article
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- Uncovering the components of the Francisella tularensis virulence stealth strategy.Frontiers in cellular and infection microbiology · 2014Review
- A novel bacterial enzyme with D-glucuronyl C5-epimerase activity.The Journal of biological chemistry · 2013Article
- Development of diagnostic and vaccine markers through cloning, expression, and regulation of putative virulence-protein-encoding genes of Aeromonas hydrophila.Journal of microbiology (Seoul, Korea) · 2013Review
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- Characterization of an actin-targeting ADP-ribosyltransferase from Aeromonas hydrophila.The Journal of biological chemistry · 2012Article
- The main Aeromonas pathogenic factors.ISRN microbiology · 2012Article
- Molecular cloning, sequence analysis and structure modeling of OmpR, the response regulator of Aeromonas hydrophila.Molecular biology reports · 2012Article
- Molecular cloning, sequence analysis and homology modeling of galE encoding UDP-galactose 4-epimerase of Aeromonas hydrophila.Bioinformation · 2009Article
- The Aeromonas hydrophila wb*O34 gene cluster: genetics and temperature regulation.Journal of bacteriology · 2008Article
- Identification of Aeromonas veronii genes required for colonization of the medicinal leech, Hirudo verbana.Journal of bacteriology · 2007Article
- The UDP N-acetylgalactosamine 4-epimerase gene is essential for mesophilic Aeromonas hydrophila serotype O34 virulence.Infection and immunity · 2006Article
Corrections and comments
- Erratum issued
Authors and funding
3 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The sequences of the O-antigen and capsule gene clusters of the virulent Aeromonas hydrophila strain PPD134/91 were determined. The O-antigen gene cluster is 17,296 bp long and comprises 17 genes. Seven pathway genes for the synthesis of rhamnose and mannose, six transferase genes, one O unit flippase gene, and one O-antigen chain length determinant gene were identified by amino acid sequence similarity. PCR and Southern blot analysis were performed to survey the distribution of these 17 genes among 11 A. hydrophila strains of different serotypes. A. hydrophila PPD134/91 might belong to serotype O:18, as represented by JCM3980; it contained all the same O-antigen genes as JCM3980 (97 to 100% similarity at the DNA and amino acid levels). The capsule gene cluster of A. hydrophila PPD134/91 is 17,562 bp long and includes 13 genes, which were assembled into three distinct regions similar to those of the group II capsule gene cluster of Escherichia coli and other bacteria. Regions I and III contained four and two capsule transport genes, respectively. Region II had five genes which were highly similar to capsule synthesis pathway genes found in other bacteria. Both the purified O-antigen and capsular polysaccharides increased the ability of the avirulent A. hydrophila strain PPD35/85 to survive in naïve tilapia serum. However, the purified surface polysaccharides had no inhibitory effect on the adhesion of A. hydrophila PPD134/91 to carp epithelial cells.
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