ArticleInfection and immunity2002
Protection against bacterial superantigen staphylococcal enterotoxin B by passive vaccination.
Article in Infection and immunity, 2002. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 40 papers.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
40 citing papers in PubMed, 124 citations in OpenAlex.
- Characterization of infecting strains and superantigen-neutralizing antibodies in Staphylococcus aureus bacteremia.Clinical and vaccine immunology : CVI · 2011Trial
- Passive Immunotherapy of Cynomolgus Monkeys with Anti-Rotavirus IgY.Pharmaceutics · 2024Article
- Respiratory tract infections: an update on the complexity of bacterial diversity, therapeutic interventions and breakthroughs.Archives of microbiology · 2024Review
- IgY antibodies: The promising potential to overcome antibiotic resistance.Frontiers in immunology · 2023Review
- IgY Targeting Bacterial Quorum-Sensing Molecules in Implant-Associated Infections.Molecules (Basel, Switzerland) · 2020Article
- Determining the immunological characteristics of a novel human monoclonal antibody developed against staphylococcal enterotoxin B.Human vaccines & immunotherapeutics · 2020Article
- Review
- Egg yolk antibodies (IgY) and their applications in human and veterinary health: A review.International immunopharmacology · 2019Review
- Effects of specific egg yolk immunoglobulin on pan-drug-resistant Acinetobacter baumannii.Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie · 2017Article
- An Update on Clinical Burden, Diagnostic Tools, and Therapeutic Options ofInfectious diseases · 2017Review
- IgY antibodies in human nutrition for disease prevention.Nutrition journal · 2015Review
- Neutralization of staphylococcal enterotoxin B by an aptamer antagonist.Antimicrobial agents and chemotherapy · 2015Article
- Article
- Article
- Staphylococcal Enterotoxin B-specific monoclonal antibody 20B1 successfully treats diverse Staphylococcus aureus infections.The Journal of infectious diseases · 2013Article
- Bacterial Toxins-Staphylococcal Enterotoxin B.Microbiology spectrum · 2013Article
- The staphylococcal enterotoxin (SE) family: SEB and siblings.Virulence · 2013Review
- Novel synthetic (poly)glycerolphosphate-based antistaphylococcal conjugate vaccine.Infection and immunity · 2013Article
- Avian IgY antibodies and their recombinant equivalents in research, diagnostics and therapy.Biologicals : journal of the International Association of Biological Standardization · 2012Review
- The potential use of toxin antibodies as a strategy for controlling acute Staphylococcus aureus infections.Expert opinion on therapeutic targets · 2012Review
Corrections and comments
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Authors and funding
3 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
We investigated the ability of two overlapping fragments of staphylococcal enterotoxin B (SEB), which encompass the whole toxin, to induce protection and also examined if passive transfer of chicken anti-SEB antibodies raised against the holotoxin could protect rhesus monkeys against aerosolized SEB. Although both fragments of SEB were highly immunogenic, the fragments failed to protect mice whether they were injected separately or injected together. Passive transfer of antibody generated in chickens (immunoglobulin Y [IgY]) against the whole toxin suppressed cytokine responses and was protective in mice. All rhesus monkeys treated with the IgY specific for SEB up to 4 h after challenge survived lethal SEB aerosol exposure. These findings suggest that large fragments of SEB may not be ideal for productive vaccination, but passive transfer of SEB-specific antibodies protects nonhuman primates against lethal aerosol challenge. Thus, antibodies raised in chickens against the holotoxin may have potential therapeutic value within a therapeutic window of opportunity after SEB encounter.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.