ReviewGut2002
Immunoregulation in the gut: success and failures in human disease.
Review in Gut, 2002. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT00261118 (Phase 3), which is not on this map. Cited by 45 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Phase 3: Randomised Controlled Trial of Rituximab in Active Ulcerative Colitis
Who cites it
45 citing papers in PubMed, 122 citations in OpenAlex.
- Laparoscopic versus open ileo-colonic resection in Crohn's disease: short- and long-term results from a prospective longitudinal study.Journal of gastrointestinal surgery : official journal of the Society for Surgery of the Alimentary Tract · 2008Trial
- Trial
- 99mTc-interleukin-2 and (99m)Tc-HMPAO granulocyte scintigraphy in patients with inactive Crohn's disease.European journal of nuclear medicine and molecular imaging · 2003Trial
- Using laxative to recover intestinal function could improve the survival outcome for patients with cardiac arrest: a retrospective cohort study from MIMIC-IV database.Journal of intensive care · 2026Article
- Gut redox and microbiome: charting the roadmap to T-cell regulation.Frontiers in immunology · 2024Review
- The chromatin and single-cell transcriptional landscapes of CD4 T cells in inflammatory bowel disease link risk loci with a proinflammatory Th17 cell population.Frontiers in immunology · 2023Article
- Fecal Microbiota Transplantation (FMT) Alleviates Experimental Colitis in Mice by Gut Microbiota Regulation.Journal of microbiology and biotechnology · 2020Article
- Protective effects of fermented rice extract on ulcerative colitis induced by dextran sodium sulfate in mice.Food science & nutrition · 2020Article
- Ginseng berry polysaccharides on inflammation-associated colon cancer: inhibiting T-cell differentiation, promoting apoptosis, and enhancing the effects of 5-fluorouracil.Journal of ginseng research · 2020Article
- Dietary Supplementation of Fermented Rice Bran Effectively Alleviates Dextran Sodium Sulfate-Induced Colitis in Mice.Nutrients · 2017Article
- Catalpol reduces the production of inflammatory mediators via PPAR-γ activation in human intestinal Caco-2 cells.Journal of natural medicines · 2016Article
- MALT1 inhibitors prevent the development of DSS-induced experimental colitis in mice via inhibiting NF-κB and NLRP3 inflammasome activation.Oncotarget · 2016Article
- The Immunological Basis of Inflammatory Bowel Disease.Gastroenterology research and practice · 2016Review
- Efficacy and Safety of Long-Term Thiopurine Maintenance Treatment in Japanese Patients With Ulcerative Colitis.Intestinal research · 2015Article
- The gastrointestinal microbiota and colorectal cancer.American journal of physiology. Gastrointestinal and liver physiology · 2015Review
- Regulation of CD4 T-cell differentiation and inflammation by repressive histone methylation.Immunology and cell biology · 2015Review
- Crotoxin from Crotalus durissus terrificus is able to down-modulate the acute intestinal inflammation in mice.PloS one · 2015Article
- Animal models of inflammatory bowel disease: a review.Inflammopharmacology · 2014Review
- Effect of salicin on gut inflammation and on selected groups of gut microbiota in dextran sodium sulfate induced mouse model of colitis.Inflammation research : official journal of the European Histamine Research Society ... [et al.] · 2014Article
- HIV Infection is associated with compositional and functional shifts in the rectal mucosal microbiota.Microbiome · 2013Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
In normal conditions, human gut mucosa is infiltrated with a large number of mononuclear cells. This is a reflection of the fact that human intestine is continuously subjected to a massive stimulation by luminal antigens. This state of "physiological" inflammation is a tightly controlled phenomenon, as several mucosal cells interact to generate and maintain an appropriate local immune response. Changes in cell type number and/or function, including the release of soluble mediators, have been associated with the development of chronic inflammatory diseases, such as Crohn's disease (CD) and ulcerative colitis (UC), the two major forms of inflammatory bowel disease. Evidence also indicates that the type of inflammatory response occurring in the intestine of patients with CD differs from that in UC, and this probably reflects distinct pathways of immune activation. In CD mucosa, a Th1 response with high IL-12 and IFNgamma production prevails, while in UC a humoral immunity appears to be predominant. Despite this, CD and UC share downstream inflammatory events, characterised by high levels of inflammatory cytokines, free radicals, matrix-degrading enzymes and growth factors.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.