Evidence map›Paper›PMID 11953326›Full record

ReviewGut2002

Toxins and the gut: role in human disease.

A Fasano

Open access · bronzeAbstract readReview
In one paragraph

Review in Gut, 2002. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.

0numbers the graph read from it
0cells of the map it votes in
23citing papers in PubMed
1.8field-weighted citation impact, top 15% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

23 citing papers in PubMed, 74 citations in OpenAlex.

  1. The Comparative Characterization of a HypervirulentInternational journal of molecular sciences · 2024
    Article
  2. Article
  3. Article
  4. Review
  5. Review
  6. Article
  7. Review
  8. Review
  9. Review
  10. Article
  11. Analysis of theFrontiers in cellular and infection microbiology · 2020
    Article
  12. Article
  13. AFrontiers in cellular and infection microbiology · 2017
    Article
  14. Article
  15. Article
  16. Infectious diarrhea: an overview.Current gastroenterology reports · 2014
    Review
  17. Article
  18. Review
  19. Appraisal of microbial evolution to commensalism and pathogenicity in humans.Clinical medicine insights. Gastroenterology · 2013
    Review
  20. Roles of zinc in the pathophysiology of acute diarrhea.Current infectious disease reports · 2012
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

1 author at 1 institution in 1 country.

A FasanoDivision of Pediatric Gastroenterology and Nutrition, University of Maryland School of Medicine, Baltimore, MD 21201, USA. afasano@umaryland.edu
University of Maryland, Baltimore · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Bacterial enteric infections exact a heavy toll on the human population, particularly among children. Despite the explosion of knowledge on the pathogenesis of enteric diseases experienced during the past decade, the number of diarrhoeal episodes and human deaths reported worldwide remains of apocalyptic dimensions. However, our better understanding of the pathogenic mechanisms involved in the onset of diarrhoea is finally leading to preventive interventions, such as the development of enteric vaccines, that may have a significant impact on the magnitude of this human plague. The application of a multidisciplinary approach to study bacterial pathogenesis, along with the recent sequencing of entire microbial genomes, have made possible discoveries that are changing the way scientists view the bacterium-host interaction. Today, research on the molecular basis of the pathogenesis of infective diarrhoeal diseases of necessity transcends established boundaries between microbiology, cell biology, intestinal pathophysiology, and immunology. This review focuses on the most recent outcomes of this multidisciplinary effort.

Indexed as

Signal TransductionActinsBacterial InfectionsBacterial TranslocationCalciumCyclic AMPCytoskeletonDiarrheaEnterocytesEnterotoxinsHumansNitric OxideProtein BiosynthesisTight JunctionsActinsCalciumCyclic AMPEnterotoxinsNitric Oxide

Identifiers

PMID11953326
PMCPMC1867677
OpenAlexW2056782399

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.