ArticlePlant physiology2002
Regulation by polyamines of ornithine decarboxylase activity and cell division in the unicellular green alga Chlamydomonas reinhardtii.
Article in Plant physiology, 2002. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers.
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Who cites it
29 citing papers in PubMed, 96 citations in OpenAlex.
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- Molecular Insights into the Synergistic Effects of Putrescine and Ammonium on Dinoflagellates.International journal of molecular sciences · 2024Article
- From Feasting to Fasting: The Arginine Pathway as a Metabolic Switch in Nitrogen-DeprivedCells · 2023Review
- Advanced pathway engineering for phototrophic putrescine production.Plant biotechnology journal · 2022Article
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- The Spermidine Synthase GeneCells · 2022Article
- Alternative Splicing During theG3 (Bethesda, Md.) · 2020Article
- Ornithine Decarboxylase-Mediated Production of Putrescine Influences Ganoderic Acid Biosynthesis by Regulating Reactive Oxygen Species in Ganoderma lucidum.Applied and environmental microbiology · 2017Article
- A refined genome-scale reconstruction of Chlamydomonas metabolism provides a platform for systems-level analyses.The Plant journal : for cell and molecular biology · 2015Article
- Proteome regulation during Olea europaea fruit development.PloS one · 2013Article
- Thiol synthetases of legumes: immunogold localization and differential gene regulation by phytohormones.Journal of experimental botany · 2012Article
- Characterization of transcriptome dynamics during watermelon fruit development: sequencing, assembly, annotation and gene expression profiles.BMC genomics · 2011Article
- Bacterial and plant signal integration via D3-type cyclins enhances symptom development in the Arabidopsis-Rhodococcus fascians interaction.Plant physiology · 2011Article
- Synergistic effect of kinetin and spermine on some physiological aspects of seawater stressed Vigna sinensis plants.Saudi journal of biological sciences · 2011Article
- Article
- Organ-specific defence strategies of pepper (Capsicum annuum L.) during early phase of water deficit.Plant cell reports · 2010Article
- Genome-wide analysis of alternative splicing in Chlamydomonas reinhardtii.BMC genomics · 2010Article
- Excretion of polyamines in alfalfa and tobacco suspension-cultured cells and its possible role in maintenance of intracellular polyamine contents.Plant cell reports · 2008Article
- High quality metabolomic data for Chlamydomonas reinhardtii.Plant methods · 2008Article
Corrections and comments
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Polyamines are required for cell growth and cell division in eukaryotic and prokaryotic organisms. In the unicellular green alga Chlamydomonas reinhardtii, biosynthesis of the commonly occurring polyamines (putrescine, spermidine, and spermine) is dependent on the activity of ornithine decarboxylase (ODC, EC 4.1.1.17) catalyzing the formation of putrescine, which is the precursor of the other two polyamines. In synchronized C. reinhardtii cultures, transition to the cell division phase was preceded by a 4-fold increase in ODC activity and a 10- and a 20-fold increase, respectively, in the putrescine and spermidine levels. Spermine, however, could not be detected in C. reinhardtii cells. Exogenous polyamines caused a decrease in ODC activity. Addition of spermine, but not of spermidine or putrescine, abolished the transition to the cell division phase when applied 7 to 8 h after beginning of the light (growth) phase. Most of the cells had already doubled their cell mass after this growth period. The spermine-induced cell cycle arrest could be overcome by subsequent addition of spermidine or putrescine. The conclusion that spermine affects cell division via a decreased spermidine level was corroborated by the findings that spermine caused a decrease in the putrescine and spermidine levels and that cell divisions also could be prevented by inhibitors of S-adenosyl-methionine decarboxylase and spermidine synthase, respectively, added 8 h after beginning of the growth period. Because protein synthesis was not decreased by addition of spermine under our experimental conditions, we conclude that spermidine affects the transition to the cell division phase directly rather than via protein biosynthesis.
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