ArticlePlant physiology2002
Pharmacological analysis of nod factor-induced calcium spiking in Medicago truncatula. Evidence for the requirement of type IIA calcium pumps and phosphoinositide signaling.
Article in Plant physiology, 2002. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 39 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
39 citing papers in PubMed, 90 citations in OpenAlex.
- Synergistic melatonin and myo-inositol application reinforces antioxidant defence, osmotic homeostasis, and membrane stability in Western Himalayan apple rootstocks under drought stress.BMC plant biology · 2026Article
- Metabolite-mediated enhancement of drought resilience in north-western Himalayan apple rootstocks through synergistic modulation of physiological performance.Scientific reports · 2026Article
- Constitutive activation of a nuclear-localized calcium channel complex inProceedings of the National Academy of Sciences of the United States of America · 2022Article
- The Importance of Glycerophospholipid Production to the Mutualist Symbiosis of Trypanosomatids.Pathogens (Basel, Switzerland) · 2021Article
- Calcium dynamics in tomato pollen tubes using the Yellow Cameleon 3.6 sensor.Plant reproduction · 2018Article
- An Autophagy-Related Kinase Is Essential for the Symbiotic Relationship betweenThe Plant cell · 2016Article
- Does a Common Pathway Transduce Symbiotic Signals in Plant-Microbe Interactions?Frontiers in plant science · 2016Article
- Genome-Wide Identification and Expression Analysis of the 14-3-3 Family Genes in Medicago truncatula.Frontiers in plant science · 2016Article
- A role for the mevalonate pathway in early plant symbiotic signaling.Proceedings of the National Academy of Sciences of the United States of America · 2015Article
- Biochemical and phylogenetic analyses of phosphatidylinositol production in Angomonas deanei, an endosymbiont-harboring trypanosomatid.Parasites & vectors · 2015Article
- Genome-wide identification and expression analysis of auxin response factor gene family in Medicago truncatula.Frontiers in plant science · 2015Article
- Genome-Wide Analysis and Expression Profiling of the Phospholipase C Gene Family in Soybean (Glycine max).PloS one · 2015Article
- Genome-wide identification of CAMTA gene family members in Medicago truncatula and their expression during root nodule symbiosis and hormone treatments.Frontiers in plant science · 2015Article
- Endosymbiosis in trypanosomatid protozoa: the bacterium division is controlled during the host cell cycle.Frontiers in microbiology · 2015Article
- Article
- Nuclear calcium signaling in plants.Plant physiology · 2013Review
- Towards the Physics of Calcium Signalling in Plants.Plants (Basel, Switzerland) · 2013Review
- CPK3-phosphorylated RhoGDI1 is essential in the development of Arabidopsis seedlings and leaf epidermal cells.Journal of experimental botany · 2013Article
- Speak, friend, and enter: signalling systems that promote beneficial symbiotic associations in plants.Nature reviews. Microbiology · 2013Review
- The non-specific lipid transfer protein N5 of Medicago truncatula is implicated in epidermal stages of rhizobium-host interaction.BMC plant biology · 2012Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Bacterial Nod factors trigger a number of cellular responses in root hairs of compatible legume hosts, which include periodic, transient increases in cytosolic calcium levels, termed calcium spiking. We screened 13 pharmaceutical modulators of eukaryotic signal transduction for effects on Nod factor-induced calcium spiking. The purpose of this screening was 2-fold: to implicate enzymes required for Nod factor-induced calcium spiking in Medicago sp., and to identify inhibitors of calcium spiking suitable for correlating calcium spiking to other Nod factor responses to begin to understand the function of calcium spiking in Nod factor signal transduction. 2-Aminoethoxydiphenylborate, caffeine, cyclopiazonic acid (CPA), 2,5-di-(t-butyl)-1,4-hydroquinone, and U-73122 inhibit Nod factor-induced calcium spiking. CPA and U-73122 are inhibitors of plant type IIA calcium pumps and phospholipase C, respectively, and implicate the requirement for these enzymes in Nod factor-induced calcium spiking. CPA and U-73122 inhibit Nod factor-induced calcium spiking robustly at concentrations with no apparent toxicity to root hairs, making CPA and U-73122 suitable for testing whether calcium spiking is causal to subsequent Nod factor responses.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.