ArticlePlant physiology2002
Characterization of CAX4, an Arabidopsis H(+)/cation antiporter.
Article in Plant physiology, 2002. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 45 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
45 citing papers in PubMed, 130 citations in OpenAlex.
- Resources of manganese hyperaccumulators and mechanisms of plant tolerance to excess manganese: A review.Planta · 2026Review
- Structural basis of CAX1 autoinhibition by its amino-terminal domain in Arabidopsis thaliana.Nature plants · 2025Article
- Evolution and diversification of CaBMC plant biology · 2025Article
- Aluminum-mediated alleviation of manganese toxicity in Malus robusta Rehd.: insights into mechanisms and implications.Plant cell reports · 2025Article
- The genetic basis of chloride exclusion in grapevines.G3 (Bethesda, Md.) · 2025Article
- Functional differentiation and genetic diversity of rice cation exchanger (CAX) genes and their potential use in rice improvement.Scientific reports · 2024Article
- TaHRC suppresses the calcium-mediated immune response and triggers wheat Fusarium head blight susceptibility.Plant physiology · 2022Article
- CaProceedings of the National Academy of Sciences of the United States of America · 2022Article
- Quantitative Trait Locus Mapping of Marsh Spot Disease Resistance in Cranberry Common Bean (International journal of molecular sciences · 2022Article
- MTP8 fromInternational journal of molecular sciences · 2022Article
- Transport, functions, and interaction of calcium and manganese in plant organellar compartments.Plant physiology · 2021Review
- Identification of genes related to tipburn resistance in Chinese cabbage and preliminary exploration of its molecular mechanism.BMC plant biology · 2021Article
- The CaCA superfamily genes in Saccharum: comparative analysis and their functional implications in response to biotic and abiotic stress.BMC genomics · 2021Article
- Description of AtCAX4 in Response to Abiotic Stress in Arabidopsis.International journal of molecular sciences · 2021Article
- Physiological and transcriptomic analyses reveal the roles of secondary metabolism in the adaptive responses of Stylosanthes to manganese toxicity.BMC genomics · 2020Article
- Expression of Genes Involved in Heavy Metal Trafficking in Plants Exposed to Salinity Stress and Elevated Cd Concentrations.Plants (Basel, Switzerland) · 2020Article
- Manganese in Plants: From Acquisition to Subcellular Allocation.Frontiers in plant science · 2020Review
- Chloroplast Calcium Signaling in the Spotlight.Frontiers in plant science · 2020Review
- Advances in the Mechanisms of Plant Tolerance to Manganese Toxicity.International journal of molecular sciences · 2019Review
- Transcriptome-Wide Identification and Characterization of Circular RNAs in Leaves of Chinese Cabbage (Brassica rapa L. ssp. pekinensis) in Response to Calcium Deficiency-Induced Tip-burn.Scientific reports · 2019Article
Corrections and comments
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Authors and funding
4 authors at 3 institutions in 1 country.
Funding
Abstract
Ion compartmentalization is essential for plant growth and development. The Arabidopsis open reading frames for CAX1, CAX2, and CAX3 (cation exchangers 1, 2, and 3) were previously identified as transporters that may modulate ion fluxes across the vacuolar membrane. To understand the diversity and role of H(+)/cation transporters in controlling plant ion levels, another homolog of the CAX genes, CAX4, was cloned from an Arabidopsis cDNA library. CAX4 is 53% identical to CAX1 at the amino acid level, 42% identical to CAX2, and 54% identical to CAX3. CAX4 transcripts appeared to be expressed at low levels in all tissues and levels of CAX4 RNA increased after Mn(2+), Na(+), and Ni(2+) treatment. An N-terminal CAX4-hemagglutinin fusion appeared to localize to both yeast and plant vacuolar membranes. When expressed in yeast, CAX4, like CAX3, failed to suppress the Ca(2+) sensitivity of yeast strains deficient in vacuolar Ca(2+) transport. Several modifications to CAX4 allowed the protein to transport Ca(2+). Addition of amino acids to the N terminus of CAX4 and CAX3 caused both transporters to suppress the sensitivity of yeast strains deficient in vacuolar Ca(2+) transport. These findings suggest that CAX transporters may modulate their ion transport properties through alterations at the N terminus.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.