ArticleMolecular pathology : MP2002
Potential viral pathogenic mechanism for new variant inflammatory bowel disease.
Article in Molecular pathology : MP, 2002. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
24 citing papers in PubMed, 182 citations in OpenAlex.
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- Significance of neurexin and neuroligin polymorphisms in regulating risk of Hirschsprung's disease.Journal of investigative medicine : the official publication of the American Federation for Clinical Research · 2018Article
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- Reference genes in real-time PCR.Journal of applied genetics · 2013Review
- PCR: living life amplified and standardized.Nature methods · 2013Article
- Microbe hunting.Microbiology and molecular biology reviews : MMBR · 2010Review
- Routine lab method's accuracy called into question.Nature medicine · 2010Article
- Lack of association between measles virus vaccine and autism with enteropathy: a case-control study.PloS one · 2008Article
- MMR: where are we now?Archives of disease in childhood · 2007Review
- The effects of hyperbaric oxygen therapy on oxidative stress, inflammation, and symptoms in children with autism: an open-label pilot study.BMC pediatrics · 2007Article
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- Are there altered antibody responses to measles, mumps, or rubella viruses in autism?Journal of neurovirology · 2007Article
- Autistic spectrum disorder: No causal relationship with vaccines.Paediatrics & child health · 2007Article
- Autistic spectrum disorder: No causal relationship with vaccines.The Canadian journal of infectious diseases & medical microbiology = Journal canadien des maladies infectieuses et de la microbiologie medicale · 2007Article
- MMR: marginalised, misrepresented and rejected? Autism: a focus group study.Archives of disease in childhood · 2007Article
- Gastrointestinal factors in autistic disorder: a critical review.Journal of autism and developmental disorders · 2005Review
- Autistic disorder and viral infections.Journal of neurovirology · 2005Review
- Developmental biology of the enteric nervous system: pathogenesis of Hirschsprung's disease and other congenital dysmotilities.Seminars in pediatric surgery · 2004Review
Corrections and comments
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Authors and funding
11 authors at 4 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
aimsA new form of inflammatory bowel disease (ileocolonic lymphonodular hyperplasia) has been described in a cohort of children with developmental disorder. This study investigates the presence of persistent measles virus in the intestinal tissue of these patients (new variant inflammatory bowel disease) and a series of controls by molecular analysis.
methodsFormalin fixed, paraffin wax embedded and fresh frozen biopsies from the terminal ileum were examined from affected children and histological normal controls. The measles virus Fusion (F) and Haemagglutinin (H) genes were detected by TaqMan reverse transcription polymerase chain reaction (RT-PCR) and the Nucleocapsid (N) gene by RT in situ PCR. Localisation of the mRNA signal was performed using a specific follicular dendritic cell antibody.
resultsSeventy five of 91 patients with a histologically confirmed diagnosis of ileal lymphonodular hyperplasia and enterocolitis were positive for measles virus in their intestinal tissue compared with five of 70 control patients. Measles virus was identified within the follicular dendritic cells and some lymphocytes in foci of reactive follicular hyperplasia. The copy number of measles virus ranged from one to 300,00 copies/ng total RNA.
conclusionsThe data confirm an association between the presence of measles virus and gut pathology in children with developmental disorder.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.