ArticleThe Biochemical journal2002
Activation of glucokinase gene expression by hepatic nuclear factor 4alpha in primary hepatocytes.
Article in The Biochemical journal, 2002. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
14 citing papers in PubMed, 46 citations in OpenAlex.
- PAS Kinase deficiency alters the glucokinase function and hepatic metabolism.Scientific reports · 2018Article
- Article
- Transcriptional Factors Mediating Retinoic Acid Signals in the Control of Energy Metabolism.International journal of molecular sciences · 2015Review
- Hepatic glucose sensing and integrative pathways in the liver.Cellular and molecular life sciences : CMLS · 2014Review
- Roles of Vitamin A Metabolism in the Development of Hepatic Insulin Resistance.ISRN hepatology · 2013Review
- Omega-3 fatty acids for the treatment of non-alcoholic fatty liver disease.World journal of gastroenterology · 2012Review
- Menin liver-specific hemizygous mice challenged with high fat diet show increased weight gain and markers of metabolic impairment.Nutrition & diabetes · 2012Article
- Expression of the human glucokinase gene: important roles of the 5' flanking and intron 1 sequences.PloS one · 2012Article
- Article
- SREBP isoform and SREBP target gene expression during rat primary hepatocyte culture.In vitro cellular & developmental biology. Animal · 2010Article
- Transcriptional regulation of glucose sensors in pancreatic β-cells and liver: an update.Sensors (Basel, Switzerland) · 2010Review
- FoxO1 and HNF-4 are involved in regulation of hepatic glucokinase gene expression by resveratrol.The Journal of biological chemistry · 2009Article
- Molecular physiology of mammalian glucokinase.Cellular and molecular life sciences : CMLS · 2009Review
- Regulation of insulin secretion and beta-cell mass by activating signal cointegrator 2.Molecular and cellular biology · 2006Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Glucokinase (GK) is a key enzyme for glucose utilization in liver and shows a higher expression in the perivenous zone. In primary rat hepatocytes, the GK gene expression was activated by HNF (hepatic nuclear factor)-4alpha via the sequence -52/-39 of the GK promoter. Venous pO2 enhanced HNF-4 levels and HNF-4 binding to the GK-HNF-4 element. Thus, HNF-4alpha could play the role of a regulator for zonated GK expression.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.