ArticleOncogene2002
Metastasis-associated protein (MTA)1 enhances migration, invasion, and anchorage-independent survival of immortalized human keratinocytes.
Article in Oncogene, 2002. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 34 papers, 2 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
34 citing papers in PubMed, 2 syntheses or guidelines pooled it, 101 citations in OpenAlex.
- Expression and Prognostic Significance of Metastasis-Associated Protein 1 in Gastrointestinal Cancer.Frontiers in oncology · 2020Pooled it
- Role of metastasis-associated protein 1 in prognosis of patients with digestive tract cancers: A meta-analysis.PloS one · 2017Pooled it
- Metastasis-associated protein 1: A potential driver and regulator of the hallmarks of cancer.Journal of biosciences · 2022Review
- The Role of Noncoding RNAs in the Regulation of Anoikis and Anchorage-Independent Growth in Cancer.International journal of molecular sciences · 2021Review
- MTA1 is an indicator of prognosis in Chinese patients with lung adenocarcinoma.Translational cancer research · 2020Article
- Anti-oral cancer effects of triptolide by downregulation of DcR3 in vitro, in vivo, and in preclinical patient-derived tumor xenograft model.Head & neck · 2019Article
- Differential Outcomes and Biologic Markers of Radiation-Associated vs. Sporadic Osteosarcoma: A Single-Institution Experience.Frontiers in oncology · 2019Article
- HPV16-E6 Oncoprotein Activates TGF-BioMed research international · 2018Article
- Review
- MTA1 promotes metastasis of MPM via suppression of E-cadherin.Journal of experimental & clinical cancer research : CR · 2015Article
- Overexpression of MTA1 promotes invasiveness and metastasis of ovarian cancer cells.Irish journal of medical science · 2014Article
- Embryonic stem cell-specific signature in cervical cancer.Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine · 2014Review
- MTA1 promotes nasopharyngeal carcinoma growth in vitro and in vivo.Journal of experimental & clinical cancer research : CR · 2013Article
- Modulation of cancer traits by tumor suppressor microRNAs.International journal of molecular sciences · 2013Review
- Metastasis-associated protein 1 nuclear expression is closely associated with tumor progression and angiogenesis in patients with esophageal squamous cell cancer.World journal of surgery · 2012Article
- Metastasis-associated protein 1 drives tumor cell migration and invasion through transcriptional repression of RING finger protein 144A.The Journal of biological chemistry · 2012Article
- MTA1 expression correlates significantly with cigarette smoke in non-small cell lung cancer.Virchows Archiv : an international journal of pathology · 2011Article
- Bidirectional autoregulatory mechanism of metastasis-associated protein 1-alternative reading frame pathway in oncogenesis.Proceedings of the National Academy of Sciences of the United States of America · 2011Article
- TGF-β1 signaling targets metastasis-associated protein 1, a new effector in epithelial cells.Oncogene · 2011Article
- Involvement of HER-2/neu and metastasis-related proteins in the development of ileal neuroendocrine tumors.Virchows Archiv : an international journal of pathology · 2011Article
Corrections and comments
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Authors and funding
9 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The human metastasis-associated gene (MTA1), a member of the nucleosome remodeling complex with histone deacetylase activity, is frequently overexpressed in biologically aggressive epithelial neoplasms. Here, we extend this observation to squamous carcinoma cells, which express high levels of MTA1 relative to normal or immortalized keratinocytes. To address functional aspects of MTA1 expression, we established variants of human immortalized keratinocytes (HaCaT cells) by expressing MTA1 cDNA in both the sense and antisense orientations. We demonstrate that (1) forced MTA1 expression enhances migration and invasion of immortalized keratinocytes; (2) MTA1 expression is necessary but not sufficient for cell survival in the anchorage independent state; (3) MTA1 contributes to expression of the anti-apoptotic Bcl-2 family member Bcl-x(L); (4) MTA1 expression in immortalized keratinocytes depends, in part, on activation of the epidermal growth factor receptor (EGFR). These results establish that, in keratinocytes, MTA1 expression contributes to several aspects of the metastatic phenotype including survival in the anchorage independent state, migration, and invasion.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.