ArticleThe Journal of neuroscience : the official journal of the Society for Neuroscience2002
The critical role of basement membrane-independent laminin gamma 1 chain during axon regeneration in the CNS.
Article in The Journal of neuroscience : the official journal of the Society for Neuroscience, 2002. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 32 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
32 citing papers in PubMed, 103 citations in OpenAlex.
- Intramedullary injection of polymerized laminin in acute traumatic spinal cord injury: a first-in-human pilot study.Spinal cord · 2026Article
- Differentiation state and culture conditions impact neural stem/progenitor cell-derived extracellular vesicle bioactivity.Biomaterials science · 2023Article
- Cell-specific expression and function of laminin at the neurovascular unit.Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism · 2022Review
- Laminin-coated multifilament entubulation, combined with Schwann cells and glial cell line-derived neurotrophic factor, promotes unidirectional axonal regeneration in a rat model of thoracic spinal cord hemisection.Neural regeneration research · 2021Article
- Cellular Prion Protein (PrPc): Putative Interacting Partners and Consequences of the Interaction.International journal of molecular sciences · 2020Review
- Regulation of Cell Cycle Entry and Exit: A Single Cell Perspective.Comprehensive Physiology · 2019Review
- Influence of extracellular matrix components on the expression of integrins and regeneration of adult retinal ganglion cells.PloS one · 2015Article
- Tissue sparing, behavioral recovery, supraspinal axonal sparing/regeneration following sub-acute glial transplantation in a model of spinal cord contusion.BMC neuroscience · 2013Article
- Deoxyribozymes and bioinformatics: complementary tools to investigate axon regeneration.Cell and tissue research · 2012Review
- Spatiotemporal expression profiling of proteins in rat sciatic nerve regeneration using reverse phase protein arrays.Proteome science · 2012Article
- β1 integrin-focal adhesion kinase (FAK) signaling modulates retinal ganglion cell (RGC) survival.PloS one · 2012Article
- Neural stem cell niches in health and diseases.Current pharmaceutical design · 2012Review
- Krüppel-like transcription factors in the nervous system: novel players in neurite outgrowth and axon regeneration.Molecular and cellular neurosciences · 2011Review
- Quiescence and activation of stem and precursor cell populations in the subependymal zone of the mammalian brain are associated with distinct cellular and extracellular matrix signals.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2010Article
- Neurite outgrowth at the biomimetic interface.Annals of biomedical engineering · 2010Article
- Novel stem/progenitor cells with neuronal differentiation potential reside in the leptomeningeal niche.Journal of cellular and molecular medicine · 2009Article
- Cortical deficiency of laminin gamma1 impairs the AKT/GSK-3beta signaling pathway and leads to defects in neurite outgrowth and neuronal migration.Developmental biology · 2009Article
- beta1-integrin mediates myelin-associated glycoprotein signaling in neuronal growth cones.Molecular brain · 2008Article
- A novel biological function for CD44 in axon growth of retinal ganglion cells identified by a bioinformatics approach.Journal of neurochemistry · 2007Article
- Calponin is expressed by subpopulations of connective tissue cells but not olfactory ensheathing cells in the neonatal olfactory mucosa.BMC neuroscience · 2007Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors at 2 institutions in 1 country.
Funding
Abstract
We have addressed the question of whether a family of axon growth-promoting molecules known as the laminins may play a role during axon regeneration in the CNS. A narrow sickle-shaped region containing a basal lamina-independent form of laminin exists in and around the cell bodies and proximal portion of the apical dendrites of CA3 pyramidal neurons of the postnatal hippocampus. To understand the possible function of laminin in axon regeneration within this pathway, we have manipulated laminin synthesis at the mRNA level in a slice culture model of the lesioned mossy system. In this model early postnatal mossy fibers severed near the hilus can regenerate across the lesion and elongate rapidly within strata lucidum and pyramidale. In slice cultures of the postnatal day 4 hippocampus, 2 d before lesion and then continuing for 1-5 d after lesion, translation of the gamma1 chain product of laminin was reduced by using antisense oligodeoxyribonucleotides and DNA enzymes. In the setting of the lesioned organotypic hippocampal slice, astroglial repair of the lesion and overall glial patterning were unperturbed by the antisense or DNA enzyme treatments. However, unlike controls, in the treated, lesioned slices the vast majority of regenerating mossy fibers could not cross the lesion site; those that did were very much shorter than usual, and they took a meandering course. In a recovery experiment in which the DNA enzyme or antisense oligos were washed away, laminin immunoreactivity returned and mossy fiber regeneration resumed. These results demonstrate the critical role of laminin(s) in an axon regeneration model of the CNS.
Indexed as
Identifiers
11943817PMC6757543W1930709195What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.