ArticleThe Journal of neuroscience : the official journal of the Society for Neuroscience2002
The neuronal adhesion protein TAG-1 is expressed by Schwann cells and oligodendrocytes and is localized to the juxtaparanodal region of myelinated fibers.
Article in The Journal of neuroscience : the official journal of the Society for Neuroscience, 2002. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 57 papers.
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Who cites it
57 citing papers in PubMed, 118 citations in OpenAlex.
- TAG-1 Regulates NRP1 in Schwann Cells and Participates in Regulating Nerve Regeneration in Rats with Sciatic Nerve Crush Injury.Neurochemical research · 2024Article
- Compromised Myelin and Axonal Molecular Organization Following Adult-Onset Sulfatide Depletion.Biomedicines · 2023Article
- Glycans and Carbohydrate-Binding/Transforming Proteins in Axon Physiology.Advances in neurobiology · 2023Article
- Pathology of Initial Axon Segments in Chronic Inflammatory Demyelinating Polyradiculoneuropathy and Related Disorders.International journal of molecular sciences · 2022Review
- Models and methods to study Schwann cells.Journal of anatomy · 2022Review
- Serum contactin-1 as a biomarker of long-term disease progression in natalizumab-treated multiple sclerosis.Multiple sclerosis (Houndmills, Basingstoke, England) · 2022Article
- Pathophysiology of the Different Clinical Phenotypes of Chronic Inflammatory Demyelinating Polyradiculoneuropathy (CIDP).International journal of molecular sciences · 2021Review
- Implication of Contactins in Demyelinating Pathologies.Life (Basel, Switzerland) · 2021Review
- UniProt-Related Documents (UniReD): assisting wet lab biologists in their quest on finding novel counterparts in a protein network.NAR genomics and bioinformatics · 2020Article
- A Panel of Exosome-Derived miRNAs of Cerebrospinal Fluid for the Diagnosis of Moyamoya Disease.Frontiers in neuroscience · 2020Article
- Genetic Analysis of the Organization, Development, and Plasticity of Corneal Innervation in Mice.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2019Article
- Contactins in the central nervous system: role in health and disease.Neural regeneration research · 2019Review
- Ablation of CNTN2+ Pyramidal Neurons During Development Results in Defects in Neocortical Size and Axonal Tract Formation.Frontiers in cellular neuroscience · 2019Article
- miR-3075 Inhibited the Migration of Schwann Cells by Targeting Cntn2.Neurochemical research · 2018Article
- Contactin-2, a synaptic and axonal protein, is reduced in cerebrospinal fluid and brain tissue in Alzheimer's disease.Alzheimer's research & therapy · 2018Article
- Beta secretase activity in peripheral nerve regeneration.Neural regeneration research · 2017Review
- Contactin-2/TAG-1, active on the front line for three decades.Cell adhesion & migration · 2017Article
- IntragenicMolecular syndromology · 2017Review
- The sugar code in neuronal physiology.Histochemistry and cell biology · 2017Review
- Dual specificity phosphatase 15 regulates Erk activation in Schwann cells.Journal of neurochemistry · 2017Article
Corrections and comments
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Authors and funding
4 authors at 2 institutions in 2 countries.
Funding
Abstract
The neural cell adhesion molecule TAG-1, which is a glycosylphosphatidylinositol-linked member of the Ig superfamily, is expressed by various neuronal populations in the developing CNS and PNS. We demonstrate here that Schwann cells and oligodendrocytes also express TAG-1. In the PNS, TAG-1 is detected in ensheathing Schwann cells early postnatally and is maintained throughout adulthood. In mature myelinated fibers of the CNS and PNS, TAG-1 is localized to the juxtaparanodal region. The CNS of the UDP-galactose ceramide galactosyl transferase(-/-) (CGT(-/-)) mouse mutants, which do not synthesize the abundant galactolipids of myelin, display severely disrupted axoglial interactions at the paranodal region. In contrast, axoglial interactions in the PNS of these mutants are less affected. Interestingly, TAG-1 localization is completely undetected in myelinated fibers of the CNS. In the PNS of these mutants, TAG-1 abnormally localizes in the paranodal region. These data raise the intriguing possibility that TAG-1 localization in the juxtaparanodal area mediates, or at least requires, the axoglial contact normally displayed in this region. The abnormal localization of TAG-1 in the CGT mutants might contribute to the disrupted axoglial interactions observed in these animals.
Indexed as
Identifiers
11943804PMC6757518W1592361857What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.