ArticleThe Journal of neuroscience : the official journal of the Society for Neuroscience2002
Opioid peptides inhibit excitatory but not inhibitory synaptic transmission in the rat dorsal motor nucleus of the vagus.
Article in The Journal of neuroscience : the official journal of the Society for Neuroscience, 2002. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 36 papers.
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Who cites it
36 citing papers in PubMed, 70 citations in OpenAlex.
- A brain-to-small intestine circuit mediates morphine-induced constipation in male mice.Nature communications · 2025Article
- Opioid Receptor-Mediated Regulation of Neurotransmission in the Brain.Frontiers in molecular neuroscience · 2022Review
- Article
- Adaptive Changes in the Central Control of Energy Homeostasis Occur in Response to Variations in Energy Status.International journal of molecular sciences · 2021Review
- Central control of gastrointestinal motility.Current opinion in endocrinology, diabetes, and obesity · 2019Review
- Observational
- Novel transmitters in brain stem vagal neurocircuitry: new players on the pitch.American journal of physiology. Gastrointestinal and liver physiology · 2018Review
- Acute high-fat diet upregulates glutamatergic signaling in the dorsal motor nucleus of the vagus.American journal of physiology. Gastrointestinal and liver physiology · 2018Article
- Vagal neurocircuitry and its influence on gastric motility.Nature reviews. Gastroenterology & hepatology · 2016Review
- Inhibitory neurotransmission regulates vagal efferent activity and gastric motility.Experimental biology and medicine (Maywood, N.J.) · 2016Review
- Exposure to a high fat diet during the perinatal period alters vagal motoneurone excitability, even in the absence of obesity.The Journal of physiology · 2015Article
- Central nervous system control of gastrointestinal motility and secretion and modulation of gastrointestinal functions.Comprehensive Physiology · 2014Review
- The role of vagal neurocircuits in the regulation of nausea and vomiting.European journal of pharmacology · 2014Review
- Prolonged acetylsalicylic-acid-supplementation-induced gastritis affects the chemical coding of the stomach innervating vagal efferent neurons in the porcine dorsal motor vagal nucleus (DMX).Journal of molecular neuroscience : MN · 2014Article
- Vagal afferent fibres determine the oxytocin-induced modulation of gastric tone.The Journal of physiology · 2013Article
- NMDA Receptor-Dependent Synaptic Activity in Dorsal Motor Nucleus of Vagus Mediates the Enhancement of Gastric Motility by Stimulating ST36.Evidence-based complementary and alternative medicine : eCAM · 2012Article
- Opioidergic consequences of dietary-induced binge eating.Physiology & behavior · 2011Article
- Plasticity of vagal brainstem circuits in the control of gastrointestinal function.Autonomic neuroscience : basic & clinical · 2011Review
- Differential organization of excitatory and inhibitory synapses within the rat dorsal vagal complex.American journal of physiology. Gastrointestinal and liver physiology · 2011Article
- Distinct target cell-dependent forms of short-term plasticity of the central visceral afferent synapses of the rat.BMC neuroscience · 2010Article
Corrections and comments
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Authors and funding
3 authors at 2 institutions in 1 country.
Funding
Abstract
Opioid peptides produce gastrointestinal inhibition and increase feeding when applied to the brainstem. The present studies were designed to determine the actions of opioid peptides on synaptic transmission within the dorsal motor nucleus of the vagus (DMV) and the localization of mu-opioid receptors. Whole-cell recordings were made from identified gastrointestinal-projecting DMV neurons in thin brainstem slices of the rat. Electrical stimulation of the nucleus of the tractus solitarius evoked EPSCs and IPSCs. In all neurons tested, methionine (Met)-enkephalin (0.003-30 microm) inhibited the peak amplitude of the EPSCs. The effect was prevented by naloxone (1 microm) as well as by naloxonazine (0.2 microm). An increase in the ratio of the evoked paired pulses indicated that the inhibition was attributable to actions at presynaptic receptors. This presynaptic inhibitory action was mimicked by [d-Ala(2), N-Me-Phe(4), Gly(5)-ol]-enkephalin (0.1 microm) and the analgesic dipeptide kyotorphin (10 microm) but not by cyclic[d-Pen(2), d-Pen(5)]-enkephalin (1 microm) and trans-3,4-dichloro-N-methyl-N-[2-(1-pyrrolidinyl)-cyclohexyl]benzeneacetamide methanesulfonate (1 microm). In contrast, the amplitude of evoked IPSCs was not altered either by Met-enkephalin or by any of the opioid receptor-selective agonists. Immunohistochemical studies revealed that nerve terminals apposing DMV neurons showed immunoreactivity to mu-opioid receptors colocalized with glutamate immunoreactivity but not glutamic acid decarboxylase immunoreactivity. These results suggest that within the DMV, mu-opioid receptors are present on the nerve terminals of excitatory but not inhibitory inputs to GI motoneurons. Such specificity may imply that the central inhibitory action of opioid peptides on gastrointestinal function targets selected pathways.
Indexed as
Identifiers
11943802PMC3062482W1577236025What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.