ArticleThe American journal of pathology2002
Primary thymic extranodal marginal-zone B-cell lymphoma of mucosa-associated lymphoid tissue type exhibits distinctive clinicopathological and molecular features.
Article in The American journal of pathology, 2002. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 37 papers.
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37 citing papers in PubMed, 112 citations in OpenAlex.
- Small biopsy diagnosis of anterior mediastinal masses: histologic, immunohistochemical, and molecular considerations.Mediastinum (Hong Kong, China) · 2026Review
- An Occult Primary Thymic Mucosa-Associated Lymphoid Tissue Lymphoma With Sjögren's Syndrome Revealed by CXCR4 TargetedJournal of cellular and molecular medicine · 2025Article
- Thymic B cells in aging and autoimmune disease.Frontiers in immunology · 2025Review
- Lambert-Eaton myasthenic syndrome with primary thymic marginal zone B-cell lymphoma: A case report.Respirology case reports · 2023Article
- Diagnostic approach to prevascular (anterior) mediastinal lymphomas: when thoracic pathology meets hematopathology.Mediastinum (Hong Kong, China) · 2023Review
- A systematic review and meta-analysis of thymic mucosa-associated lymphoid tissue lymphoma.Journal of thoracic disease · 2022Article
- Transformed diffuse large B-cell lymphoma from marginal zone lymphoma in the anterior mediastinum: A case report and review of the literature.Journal of clinical and experimental hematopathology : JCEH · 2022Review
- Plasmacytic Differentiation in MALT Lymphoma: a Clue to Paraproteinemia-an Unusual Case of MALT Lymphoma of Small Intestine with IgA Heavy Chain Production and Kappa Light Chain Restriction.Journal of gastrointestinal cancer · 2021Article
- Article
- A spectrum of Thymic mucosa-associated lymphoid tissue lymphoma and Thymic amyloidosis in the patient with Auto immune disease: a case series.Mediastinum (Hong Kong, China) · 2021Article
- Amyloid deposition in thymic extranodal marginal zone lymphoma of mucosa-associated lymphoid tissue in a patient with myasthenia gravis: A case report.Thoracic cancer · 2020Article
- [Primary thymic mucosa-associated lymphoid tissue lymphoma: 7 clinical cases report and a review of the literature].Zhonghua xue ye xue za zhi = Zhonghua xueyexue zazhi · 2020Review
- Verification of the diagnostic strategy for anterior mediastinal tumors.International journal of clinical oncology · 2019Article
- An overview on the differential diagnostics of tumors of the anterior-superior mediastinum: the pathologist's perspective.Mediastinum (Hong Kong, China) · 2019Review
- Review
- Surgery of Thymic Tumor with Persistent Left Superior Vena Cava.Annals of thoracic and cardiovascular surgery : official journal of the Association of Thoracic and Cardiovascular Surgeons of Asia · 2017Article
- Comparison of pediatric and adult lymphomas involving the mediastinum characterized by distinctive clinicopathological and radiological features.Scientific reports · 2017Article
- Two surgical cases of thymic MALT lymphoma associated with multiple lung cysts: possible association with Sjögren's syndrome.General thoracic and cardiovascular surgery · 2017Article
- [Mediastinal lymphomas].Der Pathologe · 2016Review
- T Cell/Histiocyte-Rich Large B Cell Lymphoma of the Thymus: A Diagnostic Pitfall.Case reports in hematology · 2016Article
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Authors and funding
15 authors at 10 institutions in 3 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Extranodal marginal-zone B-cell lymphoma (MZBL) of mucosa-associated lymphoid tissue (MALT) arising in the thymus is rare, with the largest series in the literature including only three cases. In the present study, we investigated 15 cases of thymic MALT lymphoma to systematically characterize its clinical, histopathological, and molecular features. There was a marked female predilection (male:female = 1:4), with a mean age of 55 years at diagnosis. There was a strong association with autoimmune disease, especially Sjögren's syndrome. Histologically, the thymic lymphoma showed the characteristic morphological features of extranodal MZBL of MALT type. Cysts were common. Prominent lymphoepithelial lesions were formed by centrocyte-like cells infiltrating and expanding the Hassall's corpuscles and epithelium lining the cysts. Plasmacytic differentiation was apparent in all cases. Notably, 13 of 15 cases expressed immunoglobulin (Ig) A phenotype; IgA expression in thymic MALT lymphoma was in striking contrast with the IgM phenotype observed in most of the Sjögren's syndrome-associated MZBLs and MALT lymphomas at other sites. Epstein-Barr virus was absent, and API2-MALT1 gene fusion, a recently reported MALT lymphoma-specific gene abnormality, was not detected in any case. Although one patient died of disease 85 months after the diagnosis, other patients were alive with overall 3-year and 5-year survival rates being 89% and 83%, respectively. Among the 22 patients reported previously and in the present series, at least 17 patients (77%) were Asians. These data indicate that thymic MALT lymphoma may represent a distinct subgroup of MALT lymphoma characterized by apparent predilection for Asians, a strong association with autoimmune disease, frequent presence of cysts, consistent plasma cell differentiation, tumor cells expressing IgA phenotype, and consistent lack of API2-MALT1 gene fusion.
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