ArticleThe American journal of pathology2002
Antibody response against perlecan and collagen types IV and VI in chronic renal allograft rejection in the rat.
Article in The American journal of pathology, 2002. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers, 1 of them a synthesis that pooled it.
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Who cites it
20 citing papers in PubMed, 1 synthesis or guideline pooled it, 83 citations in OpenAlex.
- Pemphigoid diseases in patients with end-stage kidney diseases: pathogenesis and treatment.Frontiers in immunology · 2024Pooled it
- Non-human leukocyte antigen antibodies in kidney transplantation: pathogenic mechanisms, detection methods, and clinical implications.Clinical transplantation and research · 2025Review
- Re-Evaluating the Transplant Glomerulopathy Lesion-Beyond Donor-Specific Antibodies.Transplant international : official journal of the European Society for Organ Transplantation · 2024Review
- Donor-Recipient Non-HLA Variants, Mismatches and Renal Allograft Outcomes: Evolving Paradigms.Frontiers in immunology · 2022Review
- B-cell Deficiency Attenuates Transplant Glomerulopathy in a Rat Model of Chronic Active Antibody-mediated Rejection.Transplantation · 2021Article
- Chronic transplant glomerulopathy: New insights into pathogenesis.Clinical transplantation · 2021Review
- Novel Aspects of Extracellular Vesicles in the Regulation of Renal Physiological and Pathophysiological Processes.Frontiers in cell and developmental biology · 2020Review
- Missing self triggers NK cell-mediated chronic vascular rejection of solid organ transplants.Nature communications · 2019Article
- Selective Deletion of Heparan Sulfotransferase Enzyme, Ndst1, in Donor Endothelial and Myeloid Precursor Cells Significantly Decreases Acute Allograft Rejection.Scientific reports · 2018Article
- Transplant glomerulopathy.Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc · 2018Review
- Neutrophil Protease Cleavage of Von Willebrand Factor in Glomeruli - An Anti-thrombotic Mechanism in the Kidney.EBioMedicine · 2017Article
- Impact of Non-Human Leukocyte Antigen-Specific Antibodies in Kidney and Heart Transplantation.Frontiers in immunology · 2017Review
- Article
- Role of 6-O-sulfated heparan sulfate in chronic renal fibrosis.The Journal of biological chemistry · 2014Article
- Immune responses to self-antigens (autoimmunity) in allograft rejection.Clinical transplants · 2012Article
- Biometric evidence of diet-induced obesity in Lew/Crl rats.Comparative medicine · 2011Article
- Application of proteomic analysis to the study of renal diseases.Nature reviews. Nephrology · 2009Review
- Late kidney allograft loss: what we know about it, and what we can do about it.Clinical journal of the American Society of Nephrology : CJASN · 2008Review
- Transplantation proteomics.Pediatric transplantation · 2005Review
- Telomere shortening and cellular senescence in a model of chronic renal allograft rejection.The American journal of pathology · 2003Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Chronic rejection is the leading cause of late renal transplant failure. Various structural lesions are observed in grafts undergoing chronic rejection including glomerular basement membrane (GBM) duplications. The well-established Fisher (F344) to Lewis (LEW) rat renal transplant model for chronic rejection was used to assess the presence and role of the humoral immune response against graft antigens during chronic rejection. LEW recipients of F344 allografts develop transplant glomerulopathy and produce IgG1 antibodies directed against F344 GBM preparations that are detectable 3 weeks after transplantation. Glomerular IgG1 deposition was observed that in vitro co-localized with a rabbit anti-rat GBM antiserum in rejecting F344 grafts; elution experiments of isolated glomeruli yielded IgG1 antibodies reactive in vitro with F344 GBM, but not LEW GBM. Prevention of acute rejection by transient treatment of the recipients with cyclosporin A completely abrogated the production of anti-GBM antibodies. Using proteomic techniques we identified the antigens recognized by the LEW posttransplant sera as being the heparan sulfate proteoglycan perlecan and the alpha1 chain of collagen type VI in association with the alpha5 chain of collagen type IV. In conclusion, LEW recipients of F344 kidney grafts produce IgG1 antibodies against donor type perlecan and alpha1(VI)/alpha5(IV) collagen and develop transplant glomerulopathy. These data implicate an important role for the humoral immune response in the development of glomerulopathy during chronic rejection.
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