ArticleTrends in biochemical sciences2002
Ribosome structure: revisiting the connection between translational accuracy and unconventional decoding.
Article in Trends in biochemical sciences, 2002. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 38 papers.
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Who cites it
38 citing papers in PubMed.
- Eukaryotic release factor 1 from Euplotes promotes frameshifting at premature stop codons in human cells.iScience · 2024Article
- Genome Expansion by tRNA +1 Frameshifting at Quadruplet Codons.Journal of molecular biology · 2022Review
- Coordination of -1 programmed ribosomal frameshifting by transcript and nascent chain features revealed by deep mutational scanning.Nucleic acids research · 2021Article
- Translation of Plant RNA Viruses.Viruses · 2021Review
- An RNA pseudoknot stimulates HTLV-1RNA (New York, N.Y.) · 2020Article
- Ribosome excursions during mRNA translocation mediate broad branching of frameshift pathways.Cell · 2015Article
- Optimized orthogonal translation of unnatural amino acids enables spontaneous protein double-labelling and FRET.Nature chemistry · 2014Article
- Redundancy of the genetic code enables translational pausing.Frontiers in genetics · 2014Review
- Frameshifting dynamics.Biopolymers · 2013Review
- HIV-1 frameshift efficiency is primarily determined by the stability of base pairs positioned at the mRNA entrance channel of the ribosome.Nucleic acids research · 2013Article
- Article
- Regulation of programmed ribosomal frameshifting by co-translational refolding RNA hairpins.PloS one · 2013Article
- Encoding multiple unnatural amino acids via evolution of a quadruplet-decoding ribosome.Nature · 2010Article
- A gripping tale of ribosomal frameshifting: extragenic suppressors of frameshift mutations spotlight P-site realignment.Microbiology and molecular biology reviews : MMBR · 2009Review
- Frameshifting RNA pseudoknots: structure and mechanism.Virus research · 2009Review
- A shifty stop for a hairy tail.Molecular microbiology · 2008Article
- The tri-frame model.Journal of theoretical biology · 2008Article
- Saturation mutagenesis of a +1 programmed frameshift-inducing mRNA sequence derived from a yeast retrotransposon.RNA (New York, N.Y.) · 2007Article
- Large scale comparative codon-pair context analysis unveils general rules that fine-tune evolution of mRNA primary structure.PloS one · 2007Article
- Structures of tRNAs with an expanded anticodon loop in the decoding center of the 30S ribosomal subunit.RNA (New York, N.Y.) · 2007Article
Corrections and comments
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Authors and funding
3 authors.
Funding
Abstract
The ribosome is a molecular machine that converts genetic information in the form of RNA, into protein. Recent structural studies reveal a complex set of interactions between the ribosome and its ligands, mRNA and tRNA, that indicate ways in which the ribosome could avoid costly translational errors. Ribosomes must decode each successive codon accurately, and structural data provide a clear indication of how ribosomes limit recruitment of the wrong tRNA (sense errors). In a triplet-based genetic code there are three potential forward reading frames, only one of which encodes the correct protein. Errors in which the ribosome reads a codon out of the normal reading frame (frameshift errors) occur less frequently than sense errors, although it is not clear from structural data how these errors are avoided. Some mRNA sequences, termed programmed-frameshift sites, cause the ribosome to change reading frame. Based on recent work on these sites, this article proposes that the ribosome uses the structure of the codon-anticodon complex formed by the peptidyl-tRNA, especially its wobble interaction, to constrain the incoming aminoacyl-tRNA to the correct reading frame.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.