ArticleMolecular and cellular biology2002
Distinct mutations in yeast TAF(II)25 differentially affect the composition of TFIID and SAGA complexes as well as global gene expression patterns.
Article in Molecular and cellular biology, 2002. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
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18 citing papers in PubMed, 35 citations in OpenAlex.
- The TAF10-containing TFIID and SAGA transcriptional complexes are dispensable for early somitogenesis in the mouse embryo.Development (Cambridge, England) · 2017Article
- Effect of curcumin on aged Drosophila melanogaster: a pathway prediction analysis.Chinese journal of integrative medicine · 2015Article
- dTAF10- and dTAF10b-Containing Complexes Are Required for Ecdysone-Driven Larval-Pupal Morphogenesis in Drosophila melanogaster.PloS one · 2015Article
- Article
- Architecture of the Saccharomyces cerevisiae SAGA transcription coactivator complex.The EMBO journal · 2014Article
- Genome-wide localization analysis of a complete set of Tafs reveals a specific effect of the taf1 mutation on Taf2 occupancy and provides indirect evidence for different TFIID conformations at different promoters.Nucleic acids research · 2010Article
- Quantitative mass spectrometry of TATA binding protein-containing complexes and subunit phosphorylations during the cell cycle.Proteome science · 2009Article
- Involvement of GTA protein NC2beta in neuroblastoma pathogenesis suggests that it physiologically participates in the regulation of cell proliferation.Molecular cancer · 2008Article
- Yeast two-hybrid map of Arabidopsis TFIID.Plant molecular biology · 2007Article
- TAF9b (formerly TAF9L) is a bona fide TAF that has unique and overlapping roles with TAF9.Molecular and cellular biology · 2005Article
- The nuclear import of TAF10 is regulated by one of its three histone fold domain-containing interaction partners.Molecular and cellular biology · 2005Article
- Mapping key functional sites within yeast TFIID.The EMBO journal · 2004Article
- Systematic analysis of essential yeast TAFs in genome-wide transcription and preinitiation complex assembly.The EMBO journal · 2003Article
- TAF10 (TAF(II)30) is necessary for TFIID stability and early embryogenesis in mice.Molecular and cellular biology · 2003Article
- Protein-protein interaction map for yeast TFIID.Nucleic acids research · 2003Article
- Mutations in the histone fold domain of the TAF12 gene show synthetic lethality with the TAF1 gene lacking the TAF N-terminal domain (TAND) by different mechanisms from those in the SPT15 gene encoding the TATA box-binding protein (TBP).Nucleic acids research · 2003Article
- Differential requirement of SAGA components for recruitment of TATA-box-binding protein to promoters in vivo.Molecular and cellular biology · 2002Article
- Mapping histone fold TAFs within yeast TFIID.The EMBO journal · 2002Article
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Authors and funding
8 authors at 4 institutions in 2 countries.
Funding
Abstract
The RNA polymerase II transcription factor TFIID, composed of the TATA-binding protein (TBP) and TBP-associated factors (TAF(II)s), nucleates preinitiation complex formation at protein-coding gene promoters. SAGA, a second TAF(II)-containing multiprotein complex, is involved in transcription regulation in Saccharomyces cerevisiae. One of the essential protein components common to SAGA and TFIID is yTAF(II)25. We define a minimal evolutionarily conserved 91-amino-acid region of TAF(II)25 containing a histone fold domain that is necessary and sufficient for growth in vivo. Different temperature-sensitive mutations of yTAF(II)25 or chimeras with the human homologue TAF(II)30 arrested cell growth at either the G(1) or G(2)/M cell cycle phase and displayed distinct phenotypic changes and gene expression patterns. Immunoprecipitation studies revealed that TAF(II)25 mutation-dependent gene expression and phenotypic changes correlated at least partially with the integrity of SAGA and TFIID. Genome-wide expression analysis revealed that the five TAF(II)25 temperature-sensitive mutant alleles individually affect the expression of between 18 and 33% of genes, whereas taken together they affect 64% of all class II genes. Thus, different yTAF(II)25 mutations induce distinct phenotypes and affect the regulation of different subsets of genes, demonstrating that no individual TAF(II) mutant allele reflects the full range of its normal functions.
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