ArticleMolecular and cellular biology2002
Interaction between FOG-1 and the corepressor C-terminal binding protein is dispensable for normal erythropoiesis in vivo.
Article in Molecular and cellular biology, 2002. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
29 citing papers in PubMed, 64 citations in OpenAlex.
- A novel role for Friend of GATA1 (FOG-1) in regulating cholesterol transport in murine erythropoiesis.PLoS genetics · 2025Article
- GATA1 in Normal and Pathologic Megakaryopoiesis and Platelet Development.Advances in experimental medicine and biology · 2024Review
- Systematic identification and characterization of repressive domains in Drosophila transcription factors.The EMBO journal · 2023Article
- Zfp281 (ZBP-99) plays a functionally redundant role with Zfp148 (ZBP-89) during erythroid development.Blood advances · 2019Article
- The GATA factor revolution in hematology.Blood · 2017Review
- Exploring the developmental mechanisms underlying Wolf-Hirschhorn Syndrome: Evidence for defects in neural crest cell migration.Developmental biology · 2016Review
- FOG-2 mediated recruitment of the NuRD complex regulates cardiomyocyte proliferation during heart development.Developmental biology · 2014Article
- Hematopoietic overexpression of FOG1 does not affect B-cells but reduces the number of circulating eosinophils.PloS one · 2014Article
- Transcriptional mechanisms underlying hemoglobin synthesis.Cold Spring Harbor perspectives in medicine · 2013Review
- Combinatorial regulation of tissue specification by GATA and FOG factors.Development (Cambridge, England) · 2012Review
- Article
- Friend of GATA suppresses the GATA-induced transcription of hepcidin in hepatocytes through a GATA-regulatory element in the HAMP promoter.Journal of molecular endocrinology · 2011Article
- GATA proteins work together with friend of GATA (FOG) and C-terminal binding protein (CTBP) co-regulators to control adipogenesis.The Journal of biological chemistry · 2010Article
- GATA switches as developmental drivers.The Journal of biological chemistry · 2010Review
- Role of the GATA-1/FOG-1/NuRD pathway in the expression of human beta-like globin genes.Molecular and cellular biology · 2010Article
- FOG-1-mediated recruitment of NuRD is required for cell lineage re-enforcement during haematopoiesis.The EMBO journal · 2010Article
- NuRD mediates activating and repressive functions of GATA-1 and FOG-1 during blood development.The EMBO journal · 2010Article
- Controlling hematopoiesis through sumoylation-dependent regulation of a GATA factor.Molecular cell · 2009Article
- Translational isoforms of FOG1 regulate GATA1-interacting complexes.The Journal of biological chemistry · 2009Article
- Antagonism of FOG-1 and GATA factors in fate choice for the mast cell lineage.The Journal of experimental medicine · 2008Article
Corrections and comments
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
Abstract
The hematopoietic, zinc-finger protein FOG-1 is essential for the development of the erythroid and megakaryocytic lineages. FOG-1's function in hematopoiesis is dependent on its ability to interact with the transcription factor GATA-1. FOG-1 has also been observed to interact with the corepressor molecule C-terminal binding protein (CtBP) through a peptide motif shared by all FOG family members. In this study, we confirmed that FOG-1 and CtBP interact by coimmunoprecipitation. We further demonstrate that a FOG-1 mutant unable to interact with CtBP has increased erythropoietic (but not megakaryocytic) rescue (relative to the wild type) of a FOG-1(-/-) cell line. To analyze further the physiological role of the FOG-1-CtBP interaction, we generated knock-in mice that express a FOG-1 variant unable to bind CtBP. Surprisingly, these mice are normal and fertile. Furthermore, erythropoiesis at all stages of development is normal in these mice. Erythrocyte production is similar in mutant and wild-type mice even under conditions of erythropoietic stress stimulated by either exogenously added erythropoietin or phenylhydrazine-induced anemia. Thus, despite conservation of the FOG-CtBP interaction site, the in vivo function of FOG-1 in erythroid development is not affected by its inability to interact with the corepressor CtBP.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.