ArticleNucleic acids research2002
Genes on human chromosome 19 show extreme divergence from the mouse orthologs and a high GC content.
Article in Nucleic acids research, 2002. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers.
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26 citing papers in PubMed, 54 citations in OpenAlex.
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- Dynamic Molecular Evolution of Mammalian Homeobox Genes: Duplication, Loss, Divergence and Gene Conversion Sculpt PRD Class Repertoires.Journal of molecular evolution · 2021Article
- Unusual sequence characteristics of human chromosome 19 are conserved across 11 nonhuman primates.BMC evolutionary biology · 2020Article
- Segmental aneuploidy in human blastocysts: a qualitative and quantitative overview.Reproductive biology and endocrinology : RB&E · 2019Article
- Systematic Analyses and Prediction of Human Drug Side Effect Associated Proteins from the Perspective of Protein Evolution.Genome biology and evolution · 2017Article
- Evolutionary origin and functional divergence of totipotent cell homeobox genes in eutherian mammals.BMC biology · 2016Article
- Dissecting the human protein-protein interaction network via phylogenetic decomposition.Scientific reports · 2014Article
- Locating protein-coding sequences under selection for additional, overlapping functions in 29 mammalian genomes.Genome research · 2011Article
- The genomic distribution of intraspecific and interspecific sequence divergence of human segmental duplications relative to human/chimpanzee chromosomal rearrangements.BMC genomics · 2008Article
- Similarity of synonymous substitution rates across mammalian genomes.Journal of molecular evolution · 2007Article
- Chromatin structure and evolution in the human genome.BMC evolutionary biology · 2007Article
- Transcription-related mutations and GC content drive variation in nucleotide substitution rates across the genomes of Arabidopsis thaliana and Arabidopsis lyrata.BMC evolutionary biology · 2007Article
- On the association between chromosomal rearrangements and genic evolution in humans and chimpanzees.Genome biology · 2007Article
- Almost all human genes resulted from ancient duplication.Proceedings of the National Academy of Sciences of the United States of America · 2006Article
- Analysis of transitions at two-fold redundant sites in mammalian genomes. Transition redundant approach-to-equilibrium (TREx) distance metrics.BMC evolutionary biology · 2006Article
- Is mammalian chromosomal evolution driven by regions of genome fragility?Genome biology · 2006Article
- Indel-based evolutionary distance and mouse-human divergence.Genome research · 2004Article
- Clustering of genes coding for DNA binding proteins in a region of atypical evolution of the human genome.Journal of molecular evolution · 2004Article
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Abstract
Mutational rates are known to be variable along the mammalian genome but the extent of this non-random fluctuation and their causes are less well understood. Using 5509 human and mouse orthologous genes with known chromosome positions, it is shown here that there are extreme differences in synonymous evolutionary rates between different human chromosomes when distances are measured using maximum-likelihood techniques. In particular, the average synonymous rate of genes located in human chromosome 19 is extremely high (K(s) = 1.243 substitutions/site) compared with the average of all genes (K(s) = 0.729), and significantly different from all other human chromosomes. When genes are sorted according to mouse chromosomes no such large differences are found. Strikingly, almost all genes of human chromosome 19 have very high GC content in humans but not in the mouse orthologs. More generally, correlation analysis shows that genes with very high GC content in humans have experienced the highest synonymous divergencies from the mouse. It is likely that, in such genes, the known relaxation of the isochore structure in rodents has caused an increased accumulation of synonymous substitutions in the mouse lineage, whereas the regions with the highest GC content in the human genome are accordingly maintained by a strong selective pressure.
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