ReviewMolecular neurobiology2002
Glutamate receptor genes: susceptibility factors in schizophrenia and depressive disorders?
Review in Molecular neurobiology, 2002. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
16 citing papers in PubMed, 49 citations in OpenAlex.
- Add-on memantine to valproate treatment increased HDL-C in bipolar II disorder.Journal of psychiatric research · 2013Trial
- Association of Blood Metabolomics Biomarkers with Brain Metabolites and Patient-Reported Outcomes as a New Approach in Individualized Diagnosis of Schizophrenia.International journal of molecular sciences · 2024Article
- Multiple rare inherited variants in a four generation schizophrenia family offer leads for complex mode of disease inheritance.Schizophrenia research · 2020Article
- Evaluation of the Effect of Memantine Supplementation in the Treatment of Acute Phase of Mania in Bipolar Disorder of Elderly Patients: A Double-blind Randomized Controlled Trial.Advanced biomedical research · 2018Article
- Role of calcium channels in bipolar disorder.Current psychopharmacology · 2017Article
- Cognitive manic symptoms in bipolar disorder associated with polymorphisms in the DAOA and COMT genes.PloS one · 2013Article
- The psychiatric disease risk factors DISC1 and TNIK interact to regulate synapse composition and function.Molecular psychiatry · 2011Article
- Brain imaging in pediatric obsessive-compulsive disorder.Journal of the American Academy of Child and Adolescent Psychiatry · 2008Review
- Glutamate receptor subtypes evidenced by differences in desensitization and dependence on the GLR3.3 and GLR3.4 genes.Plant physiology · 2008Article
- N-Methyl-D-aspartate receptors as a target for improved antipsychotic agents: novel insights and clinical perspectives.Psychopharmacology · 2005Review
- Modulators of the glycine site on NMDA receptors, D-serine and ALX 5407, display similar beneficial effects to clozapine in mouse models of schizophrenia.Psychopharmacology · 2005Article
- Schizophrenia genes, gene expression, and neuropathology: on the matter of their convergence.Molecular psychiatry · 2005Review
- Association of a glutamate (NMDA) subunit receptor gene (GRIN2B) with obsessive-compulsive disorder: a preliminary study.Psychopharmacology · 2004Article
- The genetics of schizophrenia.The Malaysian journal of medical sciences : MJMS · 2004Article
- Decreased phosphorylation of NMDA receptor type 1 at serine 897 in brains of patients with Schizophrenia.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2004Article
- Interactions of the mGluR5 gene with breeding and maternal factors on startle and prepulse inhibition in mice.Neurotoxicity research · 2004Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
1 author at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Schizophrenia, depression, and bipolar disorder are three major neuropsychiatric disorders that are among the leading causes of disability and have enormous economic impacts on our society. Although several neurotransmitter systems have been suggested to play a role in their etiology, we still have not identified any gene or molecular mechanism that might lead to genetic susceptibility for or protection against these neuropsychiatric disorders. The glutamatergic receptor system, and in particular the N-methyl-D-aspartate (NMDA) receptor complex, has long been implicated in their etiology. I review the current molecular evidence that supports a critical role for the glutamatergic receptor system in schizophrenia and the potential involvement of this receptor system in depression and bipolar disorder. It is likely that mutations in glutamate receptor genes might alter the risk of developing one of these disorders. Potential future research directions designed to identify these mutations and to elucidate their effect on mental health will be discussed.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.