ReviewMolecular neurobiology2002
Candidate RNA-binding proteins regulating extrasomatic mRNA targeting and translation in mammalian neurons.
Review in Molecular neurobiology, 2002. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
3 citing papers in PubMed, 15 citations in OpenAlex.
- What is the biological significance of BDNF mRNA targeting in the dendrites? Clues from epilepsy and cortical development.Molecular neurobiology · 2006Review
- The striatofugal fiber system in primates: a reevaluation of its organization based on single-axon tracing studies.Proceedings of the National Academy of Sciences of the United States of America · 2005Article
- A molecular mechanism for mRNA trafficking in neuronal dendrites.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2003Article
Corrections and comments
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Authors and funding
2 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
In mammalian neurons, long-lasting changes in the efficacy of individual synapses depend on the synthesis of new proteins. To maintain specificity, neuronal cells have to ensure that these newly synthesized proteins accumulate at the appropriate subpopulation of synapses. One way that neurons have solved this challenge appears to be the local translation of extrasomatic mRNAs in dendrites and at postsynaptic sites. Mechanisms, which regulate the targeting, translation, and stability of dendritic mRNAs, involve an organized interaction between cis-acting elements of localized transcripts and trans-acting RNA-binding proteins. The molecular identity and cellular functions of trans-acting factors that are likely to play an important role in post-transcriptional processing of extrasomatic transcripts in mammalian neurons are now being elucidated.
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Registered trials
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