ArticleBritish journal of pharmacology2002
Dextran sodium sulphate-induced colitis perturbs muscarinic cholinergic control of colonic epithelial ion transport.
Article in British journal of pharmacology, 2002. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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Who cites it
16 citing papers in PubMed, 40 citations in OpenAlex.
- Milk andAmerican journal of physiology. Gastrointestinal and liver physiology · 2024Article
- CD4Molecular medicine reports · 2022Article
- Anti-inflammatory Effect of a Novel Pectin Polysaccharide FromFrontiers in nutrition · 2022Article
- Inactivation of mTORC2 in macrophages is a signature of colorectal cancer that promotes tumorigenesis.JCI insight · 2019Article
- Maggot protein ameliorates dextran sulphate sodium-induced ulcerative colitis in mice.Bioscience reports · 2018Article
- Dextran sulfate sodium-induced chronic colitis attenuates CaAmerican journal of physiology. Cell physiology · 2018Article
- Substance-P Ameliorates Dextran Sodium Sulfate-Induced Intestinal Damage by Preserving Tissue Barrier Function.Tissue engineering and regenerative medicine · 2018Article
- Hydrogen peroxide scavenger, catalase, alleviates ion transport dysfunction in murine colitis.Clinical and experimental pharmacology & physiology · 2016Article
- Inhibiting Inducible Nitric Oxide Synthase in Enteric Glia Restores Electrogenic Ion Transport in Mice With Colitis.Gastroenterology · 2015Article
- Addition of Berberine to 5-Aminosalicylic Acid for Treatment of Dextran Sulfate Sodium-Induced Chronic Colitis in C57BL/6 Mice.PloS one · 2015Article
- Anti-inflammatory effects of the nicotinergic peptides SLURP-1 and SLURP-2 on human intestinal epithelial cells and immunocytes.BioMed research international · 2014Article
- Inhibition of Ca2+-activated Cl- channels by gallotannins as a possible molecular basis for health benefits of red wine and green tea.FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2010Article
- Alterations to enteric neural signaling underlie secretory abnormalities of the ileum in experimental colitis in the guinea pig.American journal of physiology. Gastrointestinal and liver physiology · 2009Article
- Loss of Ca-mediated ion transport during colitis correlates with reduced ion transport responses to a Ca-activated K channel opener.British journal of pharmacology · 2009Article
- Effect of Scutellariae Radix extract on experimental dextran-sulfate sodium-induced colitis in rats.World journal of gastroenterology · 2007Article
- Cholinergic regulation of epithelial ion transport in the mammalian intestine.British journal of pharmacology · 2006Review
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Authors and funding
6 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
1. Neuronal cholinergic input is an important regulator of epithelial electrolyte transport and hence water movement in the gut. 2. In this study, colitis was induced by treating mice with 4% (w v(-1)) dextran sodium-sulphate (DSS)-water for 5 days followed by 3 days of normal water. Mid-colonic segments were mounted in Ussing chambers and short-circuit current (Isc, indicates net ion movement) responses to the cholinergic agonist, carbachol (CCh; 10(-4) M)+/-tetrodotoxin, atropine (ATR), hexamethonium (HEX), naloxone or phenoxybenzamine were assessed. 3. Tissues from mice with DSS-induced colitis displayed a drop in Isc in response to CCh (-11.3+/-3.3 microA/cm(2)), while those from control mice showed a transient increase in Isc (76.3+/-13.0 microA/cm(2)). The DeltaIsc in colon from DSS-treated mice was tetrodotoxin-sensitive, atropine-insensitive and was reversed by hexamethonium (HEX+CCh=16.7+/-7.8 microA/cm(2)), indicating involvement of a nicotinic receptor. 4. CCh induced a drop in Isc in tissues from controls only when they were pretreated with the cholinergic muscarinic receptor blocker, atropine: ATR+CCh=-21.3+/-7.0 microA/cm(2). Nicotine elicited a drop in Isc in Ussing-chambered colon from both control and DSS-treated mice that was TTX-sensitive. 5. The drop in Isc evoked by CCh challenge of colonic tissue from DSS-treated mice or ATR+CCh challenge of control tissue was not significantly affected by blockade of opiate or alpha-adrenergic receptors by naloxone or phenoxybenzamine, respectively. 6. The data indicate that DSS-colitis reveals a nicotinic receptor that becomes important in cholinergic regulation of ion transport.
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