ArticleBritish journal of pharmacology2002
Neostigmine interactions with non steroidal anti-inflammatory drugs.
Article in British journal of pharmacology, 2002. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
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Who cites it
19 citing papers in PubMed.
- Dysregulated Cholinergic Signaling Inhibits Oligodendrocyte Maturation Following Demyelination.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2024Article
- Cannabinoid Analgesia in Postoperative Pain Management: From Molecular Mechanisms to Clinical Reality.International journal of molecular sciences · 2024Review
- The Antinociceptive Responses of MTDZ to Paclitaxel-Induced Peripheral Neuropathy and Acute Nociception in Mice: Behavioral, Pharmacological, and Biochemical Approaches.Pharmaceuticals (Basel, Switzerland) · 2023Article
- The effective interplay of (non-) selective NSAIDs with neostigmine in animal models of analgesia and inflammation.BMC pharmacology & toxicology · 2021Article
- Eslicarbazepine acetate interacts in a beneficial manner with standard and alternative analgesics to reduce trigeminal nociception.Psychopharmacology · 2020Article
- Physicochemical stability of binary admixtures of paracetamol and dexketoprofen-trometamol for patient-controlled analgesia use.European journal of hospital pharmacy : science and practice · 2019Article
- Antinociceptive interaction of gabapentin with minocycline in murine diabetic neuropathy.Inflammopharmacology · 2017Article
- The evolution of spinal/epidural neostigmine in clinical application: Thoughts after two decades.Saudi journal of anaesthesia · 2015Review
- Low-dose spinal neostigmine further enhances the analgesic effect of spinal bupivacaine combined with epidural dexamethasone, following orthopedic surgery.Journal of research in medical sciences : the official journal of Isfahan University of Medical Sciences · 2014Article
- Ascorbic Acid interaction with analgesic effect of morphine and tramadol in mice.Anesthesiology and pain medicine · 2014Article
- Modulation of imidazoline I2 binding sites by CR4056 relieves postoperative hyperalgesia in male and female rats.British journal of pharmacology · 2014Article
- Preparation and the biopharmaceutical evaluation for the metered dose transdermal spray of dexketoprofen.Journal of drug delivery · 2014Article
- The modern pharmacology of paracetamol: therapeutic actions, mechanism of action, metabolism, toxicity and recent pharmacological findings.Inflammopharmacology · 2013Review
- Preemptive analgesic effects of midazolam and diclofenac in rat model.Bosnian journal of basic medical sciences · 2011Article
- The determination and application of fixed-dose analgesic combinations for treating multimodal pain.The journal of pain · 2010Review
- Interactions between drugs and occupied receptors.Pharmacology & therapeutics · 2007Review
- Use of neostigmine in the management of acute postoperative pain and labour pain: a review.CNS drugs · 2006Review
- Effect of neostigmine on organ injury in murine endotoxemia: missing facts about the cholinergic antiinflammatory pathway.World journal of surgery · 2005Article
- Synergistic and additive interactions of the cannabinoid agonist CP55,940 with mu opioid receptor and alpha2-adrenoceptor agonists in acute pain models in mice.British journal of pharmacology · 2005Article
Corrections and comments
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Authors and funding
3 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
1. The common mechanism of action of non-steroidal anti-inflammatory drugs (NSAIDs) is the inhibition of the enzyme cyclo-oxygenase (COX), however, this inhibition is not enough to completely account for the efficacy of these agents in several models of acute pain. 2. It has been demonstrated that cholinergic agents can induce antinociception, but the nature of the interaction between these agents and NSAIDs drugs has not been studied. The present work evaluates, by isobolographic analysis, the interactions between the cholinergic indirect agonist neostigmine (NEO) and NSAIDs drugs, using a chemical algesiometric test. 3. Intraperitoneal (i.p.) or intrathecal (i.t.) administration of NEO and of the different NSAIDs produced dose-dependent antinociception in the acetic acid writhing test of the mouse. 4. The i.p. or i.t. co-administration of fixed ratios of ED(50) fractions of NSAIDs and NEO, resulted to be synergistic or supra-additive for the combinations ketoprofen (KETO) and NEO, paracetamol (PARA) and NEO) and diclofenac (DICLO) and NEO administered i.p. However, the same combinations administered i.t. were only additive. In addition, the combinations meloxicam (MELO) and NEO and piroxicam (PIRO) and NEO, administered either i.p. or i.t., were additive. 5. The results suggest that the co-administration of NEO with some NSAIDs (e.g. KETO, PARA or DICLO) resulted in a synergistic interaction, which may provide evidence of supraspinal antinociception modulation by the increased acetylcholine concentration in the synaptic cleft of cholinergic interneurons. The interaction obtained between neostigmine and the NSAIDs could carry important clinical implications.
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