Evidence map›Paper›PMID 11932436›Full record

ArticleJournal of virology2002

Cyclophilin a plays distinct roles in human immunodeficiency virus type 1 entry and postentry events, as revealed by spinoculation.

Andrew C S Saphire, Michael D Bobardt, Philippe A Gallay

Abstract read
In one paragraph

Article in Journal of virology, 2002. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.

0numbers the graph read from it
0cells of the map it votes in
15citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

15 citing papers in PubMed.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Andrew C S SaphireDepartment of Immunology, The Scripps Research Institute, La Jolla, California 92037, USA.
Michael D Bobardt
Philippe A Gallay

Funding

ROLE OF CYCLOPHILIN A IN THE HIV-1 LIFE CYCLER01AI046958 · NIAID · SCRIPPS RESEARCH INSTITUTE · PI GALLAY, PHILIPPE ANDRE · 2001 to 2003
$770k
ROLE OF CYCLOPHILIN A IN THE HIV-1 LIFE CYCLER21AI046958 · NIAID · SCRIPPS RESEARCH INSTITUTE · PI GALLAY, PHILIPPE ANDRE · 2000 to 2000
$305k
NIAID NIH HHS AI46958NIAID NIH HHS R01 AI046958NIAID NIH HHS R21 AI046958
6 · The paper itself

Abstract

Cyclophilin A (CypA) is necessary for effective human immunodeficiency virus type 1 (HIV-1) replication. However, the functions of CypA and the precise steps at which CypA acts in the HIV-1 life cycle remain to be determined. By using a methodology that bypasses the need for attachment factors-spinoculation-we present evidence that CypA participates in both entry and postentry events.

Indexed as

CentrifugationCyclophilin AEnzyme-Linked Immunosorbent AssayHeLa CellsHIV-1HumansPolysaccharide-LyasesCyclophilin Aheparitinsulfate lyasePolysaccharide-Lyases

Identifiers

PMID11932436
PMCPMC155090

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.