ArticleJournal of virology2002
Avian bic, a gene isolated from a common retroviral site in avian leukosis virus-induced lymphomas that encodes a noncoding RNA, cooperates with c-myc in lymphomagenesis and erythroleukemogenesis.
Article in Journal of virology, 2002. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 49 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
49 citing papers in PubMed, 1 synthesis or guideline pooled it, 151 citations in OpenAlex.
- miR-155 targets histone deacetylase 4 (HDAC4) and impairs transcriptional activity of B-cell lymphoma 6 (BCL6) in the Eμ-miR-155 transgenic mouse model.Proceedings of the National Academy of Sciences of the United States of America · 2012Pooled it
- Proviral ALV-LTR Sequence Is Essential for Continued Proliferation of the ALV-Transformed B Cell Line.International journal of molecular sciences · 2022Article
- Identification of Small Molecule Inhibitors of a Mir155 Transcriptional Reporter in Th17 Cells.Scientific reports · 2021Article
- TRIF Regulates BIC/miR-155 via the ERK Signaling Pathway to Control the ox-LDL-Induced Macrophage Inflammatory Response.Journal of immunology research · 2018Article
- Activation of gga-miR-155 by reticuloendotheliosis virus T strain and its contribution to transformation.The Journal of general virology · 2017Article
- Long-term expression of miRNA for RNA interference using a novel vector system based on a negative-strand RNA virus.Scientific reports · 2016Article
- Subgroup J avian leukosis virus infection of chicken dendritic cells induces apoptosis via the aberrant expression of microRNAs.Scientific reports · 2016Article
- MicroRNA-155 controls affinity-based selection by protecting c-MYC+ B cells from apoptosis.The Journal of clinical investigation · 2016Article
- Identification of biological targets of therapeutic intervention for clear cell renal cell carcinoma based on bioinformatics approach.Cancer cell international · 2016Article
- Development and application of SYBR Green I real-time PCR assay for the separate detection of subgroup J Avian leukosis virus and multiplex detection of avian leukosis virus subgroups A and B.Virology journal · 2015Article
- Challenges and opportunities of microRNAs in lymphomas.Molecules (Basel, Switzerland) · 2014Review
- MicroRNA-155 deficiency results in decreased macrophage inflammation and attenuated atherogenesis in apolipoprotein E-deficient mice.Arteriosclerosis, thrombosis, and vascular biology · 2014Article
- The MYC, TERT, and ZIC1 genes are common targets of viral integration and transcriptional deregulation in avian leukosis virus subgroup J-induced myeloid leukosis.Journal of virology · 2014Article
- microRNA therapies in cancer.Molecular and cellular therapies · 2014Review
- Therapeutic Opportunities for Targeting microRNAs in Cancer.Molecular and cellular therapies · 2014Article
- Article
- MicroRNAs: molecular features and role in cancer.Frontiers in bioscience (Landmark edition) · 2012Review
- Article
- Tumor suppressor BRCA1 epigenetically controls oncogenic microRNA-155.Nature medicine · 2011Article
- Cooperative control of tumor suppressor genes by a network of oncogenic microRNAs.Cell cycle (Georgetown, Tex.) · 2011Article
Corrections and comments
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Authors and funding
4 authors at 3 institutions in 1 country.
Funding
Abstract
bic is a novel gene identified at a common retroviral integration site in avian leukosis virus-induced lymphomas and has been implicated as a collaborator with c-myc in B lymphomagenesis. It lacks an extensive open reading frame and is believed to function as an untranslated RNA (W. Tam, Gene 274:157-167, 2001; W. Tam, D. Ben-Yehuda, and W. S. Hayward, Mol. Cell. Biol. 17:1490-1502, 1997). The oncogenic potential of bic, particularly its ability to cooperate with c-myc in oncogenesis, was tested directly by expressing c-myc and bic, either singly or in pairwise combination, in cultured chicken embryo fibroblasts (CEFs) and in chickens using replication-competent retrovirus vectors. Coexpression of c-myc and bic in CEFs caused growth enhancement of cells. Most importantly, chick oncogenicity assays demonstrated that bic can cooperate with c-myc in lymphomagenesis and erythroleukemogenesis. The present study provides direct evidence for the involvement of untranslated RNAs in oncogenesis and provides further support for the role of noncoding RNAs as riboregulators.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.