ArticleGenome research2002
Annotated expressed sequence tags and cDNA microarrays for studies of brain and behavior in the honey bee.
Article in Genome research, 2002. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 94 papers.
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94 citing papers in PubMed, 303 citations in OpenAlex.
- Phenotypic and genetic characterization of AfricanizedFrontiers in insect science · 2023Article
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- Differential gene expression analysis following olfactory learning in honeybee (Apis mellifera L.).PloS one · 2022Article
- Identification of long noncoding RNAs reveals the effects of dinotefuran on the brain in Apis mellifera (Hymenopptera: Apidae).BMC genomics · 2021Article
- Brain microRNAs among social and solitary bees.Royal Society open science · 2020Article
- The nuclear and mitochondrial genomes of Frieseomelitta varia - a highly eusocial stingless bee (Meliponini) with a permanently sterile worker caste.BMC genomics · 2020Article
- Comprehensive History ofGenes · 2020Review
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- The transcriptomic signature of low aggression in honey bees resembles a response to infection.BMC genomics · 2019Article
- The rise and fall of major royal jelly proteins during a honeybee (Ecology and evolution · 2019Article
- Identification of chemosensory genes from the antennal transcriptome of Indian meal moth Plodia interpunctella.PloS one · 2018Article
- In silico search, characterization and validation of new EST-SSR markers in the genus Prunus.BMC research notes · 2016Article
- Individual responsiveness to shock and colony-level aggression in honey bees: evidence for a genetic component.Behavioral ecology and sociobiology · 2014Article
- Gene co-citation networks associated with worker sterility in honey bees.BMC systems biology · 2014Article
- Finding the missing honey bee genes: lessons learned from a genome upgrade.BMC genomics · 2014Article
- More than royal food - Major royal jelly protein genes in sexuals and workers of the honeybee Apis mellifera.Frontiers in zoology · 2013Article
- Application of Cydia pomonella expressed sequence tags: Identification and expression of three general odorant binding proteins in codling moth.Insect science · 2013Article
- A SNP based high-density linkage map of Apis cerana reveals a high recombination rate similar to Apis mellifera.PloS one · 2013Article
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34 more citing papers are in PubMed but not listed here.
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Authors and funding
9 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
To accelerate the molecular analysis of behavior in the honey bee (Apis mellifera), we created expressed sequence tag (EST) and cDNA microarray resources for the bee brain. Over 20,000 cDNA clones were partially sequenced from a normalized (and subsequently subtracted) library generated from adult A. mellifera brains. These sequences were processed to identify 15,311 high-quality ESTs representing 8912 putative transcripts. Putative transcripts were functionally annotated (using the Gene Ontology classification system) based on matching gene sequences in Drosophila melanogaster. The brain ESTs represent a broad range of molecular functions and biological processes, with neurobiological classifications particularly well represented. Roughly half of Drosophila genes currently implicated in synaptic transmission and/or behavior are represented in the Apis EST set. Of Apis sequences with open reading frames of at least 450 bp, 24% are highly diverged with no matches to known protein sequences. Additionally, over 100 Apis transcript sequences conserved with other organisms appear to have been lost from the Drosophila genome. DNA microarrays were fabricated with over 7000 EST cDNA clones putatively representing different transcripts. Using probe derived from single bee brain mRNA, microarrays detected gene expression for 90% of Apis cDNAs two standard deviations greater than exogenous control cDNAs. [The sequence data described in this paper have been submitted to Genbank data library under accession nos. BI502708-BI517278. The sequences are also available at http://titan.biotec.uiuc.edu/bee/honeybee_project.htm.]
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