ReviewCurrent atherosclerosis reports2002
Mechanisms of abdominal aortic aneurysm formation.
Review in Current atherosclerosis reports, 2002. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 43 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
43 citing papers in PubMed, 118 citations in OpenAlex.
- Smooth Muscle Cell Plasticity as a Central Determinant of Plaque Stability.Current atherosclerosis reports · 2026Review
- Nicotine promotes AngII-induced abdominal aortic aortopathies in female and male mice: role of sex hormones.Clinical science (London, England : 1979) · 2025Article
- Hyaluronan synthase 3 deficiency lowers the incidence of ruptures of abdominal aortic aneurysms by reducing monocyte infiltration.Frontiers in immunology · 2025Article
- Toll-Like Receptor 2 Attenuates the Formation and Progression of Angiotensin II-Induced Abdominal Aortic Aneurysm in ApoE-/- Mice.Journal of vascular research · 2024Article
- DOCK2 Deficiency Attenuates Abdominal Aortic Aneurysm Formation-Brief Report.Arteriosclerosis, thrombosis, and vascular biology · 2023Article
- The role of phosphoinositide 3-kinases in immune-inflammatory responses: potential therapeutic targets for abdominal aortic aneurysm.Cell cycle (Georgetown, Tex.) · 2022Review
- Mouse Abdominal Aortic Aneurysm Model Induced by Perivascular Application of Elastase.Journal of visualized experiments : JoVE · 2022Article
- Ageing- and AAA-associated differentially expressed proteins identified by proteomic analysis in mice.PeerJ · 2022Article
- Imaging Biological Pathways in Abdominal Aortic Aneurysms Using Positron Emission Tomography.Arteriosclerosis, thrombosis, and vascular biology · 2021Review
- Ex vivo magnetic particle imaging of vascular inflammation in abdominal aortic aneurysm in a murine model.Scientific reports · 2020Article
- Collagen fibril abnormalities in human and mice abdominal aortic aneurysm.Acta biomaterialia · 2020Article
- AVE0991, a nonpeptide angiotensin-(1-7) mimic, inhibits angiotensin II-induced abdominal aortic aneurysm formation in apolipoprotein E knockout mice.Journal of molecular medicine (Berlin, Germany) · 2020Article
- Role of Noncoding RNAs in the Pathogenesis of Abdominal Aortic Aneurysm.Circulation research · 2019Review
- Marfan syndrome combined with huge abdominal aortic aneurysm size of 20 × 11 cm: A case report of surgical approach.Medicine · 2018Article
- Levo-Tetrahydropalmatine Attenuates Progression of Abdominal Aortic Aneurysm in an Elastase Perfusion Rat Model via Suppression of Matrix Metalloproteinase and Monocyte Chemotactic Protein-1.Medical science monitor : international medical journal of experimental and clinical research · 2018Article
- TSG-6 is highly expressed in human abdominal aortic aneurysms.The Journal of surgical research · 2017Article
- Critical Role of ADAMTS-4 in the Development of Sporadic Aortic Aneurysm and Dissection in Mice.Scientific reports · 2017Article
- Nanoparticulate delivery of agents for induced elastogenesis in three-dimensional collagenous matrices.Journal of tissue engineering and regenerative medicine · 2016Article
- Abdominal aortic aneurysms in women.Journal of vascular surgery · 2016Review
- Fibrinolytic PLGA nanoparticles for slow clot lysis within abdominal aortic aneurysms attenuate proteolytic loss of vascular elastic matrix.Materials science & engineering. C, Materials for biological applications · 2016Article
Corrections and comments
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Abdominal aortic aneurysms (AAA) are permanent dilations in the infra-renal area in which the arterial tissue is characterized by inflammation and medial degeneration. AAAs are a common vascular disorder and cause significant mortality in the aged population. Despite the high prevalence of this disease, there is limited knowledge on the mechanisms responsible for the vascular pathology. Therefore, current therapeutic options are restricted to surgical intervention and are predicated on the assumed propensity for rupture as the vessel enlarges. Current research focuses on inflammatory processes and their role in proteolytic degradation of the elastin and collagen fibers of the vessel wall. Definition of specific mechanisms would identify target sites for potential pharmacologic intervention and markedly improve the medical treatment and prognosis of AAA.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.