ArticleProceedings of the National Academy of Sciences of the United States of America2002
The Saccharomyces cerevisiae Fin1 protein forms cell cycle-specific filaments between spindle pole bodies.
Article in Proceedings of the National Academy of Sciences of the United States of America, 2002. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
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10 citing papers in PubMed, 30 citations in OpenAlex.
- The stoichiometry of the outer kinetochore is modulated by microtubule-proximal regulatory factors.The Journal of cell biology · 2019Article
- Mapping the Synthetic Dosage Lethality Network ofG3 (Bethesda, Md.) · 2017Article
- Regulation of mitosis by the NIMA kinase involves TINA and its newly discovered partner, An-WDR8, at spindle pole bodies.Molecular biology of the cell · 2013Article
- An expanded view of the eukaryotic cytoskeleton.Molecular biology of the cell · 2013Article
- An overview of Cdk1-controlled targets and processes.Cell division · 2010Article
- Quantitative proteomic analysis of purified yeast kinetochores identifies a PP1 regulatory subunit.Genes & development · 2009Article
- Latrunculin A delays anaphase onset in fission yeast by disrupting an Ase1-independent pathway controlling mitotic spindle stability.Molecular biology of the cell · 2008Article
- Regulation of transcription by Saccharomyces cerevisiae 14-3-3 proteins.The Biochemical journal · 2004Article
- The molecular function of Ase1p: evidence for a MAP-dependent midzone-specific spindle matrix. Microtubule-associated proteins.The Journal of cell biology · 2003Article
- Yeast weighs in on the elusive spindle matrix: New filaments in the nucleus.Proceedings of the National Academy of Sciences of the United States of America · 2002Article
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6 authors at 2 institutions in 1 country.
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No grant is acknowledged in the PubMed record.
Abstract
The FIN1 gene from the yeast Saccharomyces cerevisiae encodes a basic protein with putative coiled-coil regions. Here we show that in large-budded cells a green fluorescent protein-Fin1 fusion protein is visible as a filament between the two spindle pole bodies. In resting cells the protein is undetectable, and in small-budded cells it is localized in the nucleus. During late mitosis it localizes on the spindle pole bodies. Filaments of cyano fluorescent protein-tagged Fin1 colocalize with filaments of green fluorescent protein-tagged Tub1 only in large-budded cells. By electron and atomic force microscopy we showed that purified recombinant Fin1p self-assembles into filaments with a diameter of approximately 10 nm. Our results indicate that the Fin1 protein forms a cell cycle-specific filament, additional to the microtubules, between the spindle pole bodies of dividing yeast cells.
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