ArticleNature medicine2002
Efomycine M, a new specific inhibitor of selectin, impairs leukocyte adhesion and alleviates cutaneous inflammation.
Article in Nature medicine, 2002. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 27 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
27 citing papers in PubMed, 129 citations in OpenAlex.
- Tolerability and pharmacokinetics of inhaled bimosiamose disodium in healthy males.British journal of clinical pharmacology · 2007Trial
- The clinical impact of glycobiology: targeting selectins, Siglecs and mammalian glycans.Nature reviews. Drug discovery · 2021Review
- Functional exploration of the GH29 fucosidase family.Glycobiology · 2020Article
- Selectins-The Two Dr. Jekyll and Mr. Hyde Faces of Adhesion Molecules-A Review.Molecules (Basel, Switzerland) · 2020Review
- Natural Occurrence, Bioactivity and Biosynthesis of Elaiophylin Analogues.Molecules (Basel, Switzerland) · 2019Review
- Efomycins K and L From a Termite-AssociatedFrontiers in microbiology · 2019Article
- Naturally occurring cell adhesion inhibitors.Journal of natural medicines · 2018Review
- Retinoic Acid promotes interleukin-4 plasmid-dimethylsulfoxide topical transdermal delivery for treatment of psoriasis.Annals of dermatology · 2015Article
- Kv1.3 in psoriatic disease: PAP-1, a small molecule inhibitor of Kv1.3 is effective in the SCID mouse psoriasis--xenograft model.Journal of autoimmunity · 2014Article
- Site-specific immunosuppression in vascularized composite allotransplantation: prospects and potential.Clinical & developmental immunology · 2013Review
- Mechanisms and mediators of inflammation: potential models for skin rejection and targeted therapy in vascularized composite allotransplantation.Clinical & developmental immunology · 2012Review
- A Novel High-Throughput Screening Assay to Identify Inhibitors of HIV-1 gp120 Protein Interaction with DC-SIGN.Journal of antivirals & antiretrovirals · 2011Article
- A general glycomimetic strategy yields non-carbohydrate inhibitors of DC-SIGN.Chemical communications (Cambridge, England) · 2010Article
- GMI-1070, a novel pan-selectin antagonist, reverses acute vascular occlusions in sickle cell mice.Blood · 2010Article
- Junctional adhesion molecule (JAM)-B supports lymphocyte rolling and adhesion through interaction with alpha4beta1 integrin.Immunology · 2009Article
- From carbohydrate leads to glycomimetic drugs.Nature reviews. Drug discovery · 2009Review
- Targeting selectins and selectin ligands in inflammation and cancer.Expert opinion on therapeutic targets · 2007Review
- Non-carbohydrate inhibitors of the lectin DC-SIGN.Journal of the American Chemical Society · 2007Article
- Adhesion molecules in cutaneous immunity.Seminars in immunopathology · 2007Review
- [Psoriasis SCID-mouse model].Der Hautarzt; Zeitschrift fur Dermatologie, Venerologie, und verwandte Gebiete · 2006Review
Corrections and comments
- Commented on by
- Erratum issued
Authors and funding
16 authors at 4 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Specific interference with molecular mechanisms guiding tissue localization of leukocytes may be of great utility for selective immunosuppressive therapies. We have discovered and characterized efomycines, a new family of selective small-molecule inhibitors of selectin functions. Members of this family significantly inhibited leukocyte adhesion in vitro. Efomycine M, which was nontoxic and showed the most selective inhibitory effects on selectin-mediated leukocyte-endothelial adhesion in vitro, significantly diminished rolling in mouse ear venules in vivo as seen by intravital microscopy. In addition, efomycine M alleviated cutaneous inflammation in two complementary mouse models of psoriasis, one of the most common chronic inflammatory skin disorders. Molecular modeling demonstrated a spatial conformation of efomycines mimicking naturally occurring selectin ligands. Efomycine M might be efficacious in the treatment of human inflammatory disorders through a similar mechanism.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.