ArticleThe Journal of physiology2002
Voltage independence of vasomotion in isolated irideal arterioles of the rat.
Article in The Journal of physiology, 2002. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers.
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Who cites it
27 citing papers in PubMed, 65 citations in OpenAlex.
- Systems biology analysis of vasodynamics in mouse cerebral arterioles during resting state and functional hyperemia.PLoS computational biology · 2026Article
- Spontaneous vasomotion propagates along pial arterioles in the awake mouse brain like stimulus-evoked vascular reactivity.Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism · 2023Article
- Hypoxic Conditions Promote Rhythmic Contractile Oscillations Mediated by Voltage-Gated Sodium Channels Activation in Human Arteries.International journal of molecular sciences · 2021Article
- Gradual Not Sudden Change: Multiple Sites of Functional Transition Across the Microvascular Bed.Frontiers in aging neuroscience · 2021Article
- In-vivo correlations between skin metabolic oscillations and vasomotion in wild-type mice and in a model of oxidative stress.Scientific reports · 2019Article
- Intrinsic Frequencies of the Resting-State fMRI Signal: The Frequency Dependence of Functional Connectivity and the Effect of Mode Mixing.Frontiers in neuroscience · 2019Article
- Voltage-gated CaAmerican journal of physiology. Heart and circulatory physiology · 2018Article
- Role of capillary pericytes in the integration of spontaneous CaThe Journal of physiology · 2018Article
- Smooth Muscle Ion Channels and Regulation of Vascular Tone in Resistance Arteries and Arterioles.Comprehensive Physiology · 2017Review
- Rat retinal vasomotion assessed by laser speckle imaging.PloS one · 2017Article
- Intercellular ultrafast Ca(2+) wave in vascular smooth muscle cells: numerical and experimental study.Scientific reports · 2016Article
- Renal autoregulation in health and disease.Physiological reviews · 2015Review
- Expression of sarco (endo) plasmic reticulum calcium ATPase (SERCA) system in normal mouse cardiovascular tissues, heart failure and atherosclerosis.Biochimica et biophysica acta · 2014Article
- Differential effect of calcium-activated potassium and chloride channels on rat basilar artery vasomotion.Journal of Huazhong University of Science and Technology. Medical sciences = Hua zhong ke ji da xue xue bao. Yi xue Ying De wen ban = Huazhong keji daxue xuebao. Yixue Yingdewen ban · 2014Article
- Direct, intraoperative observation of ~0.1 Hz hemodynamic oscillations in awake human cortex: implications for fMRI.NeuroImage · 2014Article
- Potassium buffering in the neurovascular unit: models and sensitivity analysis.Biophysical journal · 2013Article
- Functional and morphological properties of pericytes in suburothelial venules of the mouse bladder.British journal of pharmacology · 2012Article
- Enhanced phase synchronization of blood flow oscillations between heated and adjacent non-heated sacral skin.Medical & biological engineering & computing · 2012Article
- Pacemaking through Ca2+ stores interacting as coupled oscillators via membrane depolarization.Biophysical journal · 2007Article
- Effects of arterial wall stress on vasomotion.Biophysical journal · 2006Article
Corrections and comments
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Authors and funding
3 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The cellular mechanisms underlying vasomotion of irideal arterioles from juvenile rats have been studied using electrophysiological methods, ratiometric calcium measurements and video microscopy. Vasomotion was not affected by removal of the endothelium. Spontaneous contractions were preceded by spontaneous depolarizations. Both were abolished by the intracellular calcium chelator, BAPTA AM (20 microM), but not by ryanodine (10 microM), suggesting a dependence on the cyclical release of calcium from intracellular stores, other than those operated by ryanodine receptors. Oscillations were little changed when the membrane potential of short segments of arteriole was either depolarized or hyperpolarized. When the segments were voltage clamped, oscillating inward currents were recorded, indicating that the changes in membrane potential were voltage independent. Vasomotion was preceded by intracellular calcium oscillations and both were abolished by inhibitors of phospholipase C (U73122, 10 microM), phospholipase A(2) (AACOCF(3), 30 microM) and protein kinase C (chelerythrine chloride, 5 microM, and myristoylated protein kinase C peptide, 10 microM). Inhibition of vasomotion by the dual lipoxygenase and cyclo-oxygenase inhibitor, NDGA (10 microM), the lipoxygenase inhibitor, ETI (1 microM) but not by the cyclo-oxygenase inhibitors, aspirin (10 microM) and indomethacin (10 microM), or the cytochrome P450 inhibitor 17-ODYA (10 microM), suggested an involvement of the lipoxygenase pathway. The observations suggest that vasomotion of iris arterioles is voltage independent and results from the cyclical release of calcium from IP(3)-sensitive stores which are activated by cross talk between the phospholipase C and phospholipase A(2) pathways in vascular smooth muscle.
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