ArticleThe Journal of physiology2002
Specific localization of an inwardly rectifying K(+) channel, Kir4.1, at the apical membrane of rat gastric parietal cells; its possible involvement in K(+) recycling for the H(+)-K(+)-pump.
Article in The Journal of physiology, 2002. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers.
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Who cites it
28 citing papers in PubMed, 87 citations in OpenAlex.
- Inwardly rectifying KAmerican journal of physiology. Cell physiology · 2022Review
- Kir Channel Molecular Physiology, Pharmacology, and Therapeutic Implications.Handbook of experimental pharmacology · 2021Review
- The Physiology of the Gastric Parietal Cell.Physiological reviews · 2020Review
- Physiological Significance of Ion Transporters and Channels in the Stomach and Pathophysiological Relevance in Gastric Cancer.Evidence-based complementary and alternative medicine : eCAM · 2020Review
- Glial and neuronal expression of the Inward Rectifying Potassium Channel Kir7.1 in the adult mouse brain.Journal of anatomy · 2019Article
- Chansporter complexes in cell signaling.FEBS letters · 2017Review
- Expression of Kir4.1 and Kir5.1 inwardly rectifying potassium channels in oligodendrocytes, the myelinating cells of the CNS.Brain structure & function · 2017Article
- Potassium Channelopathies and Gastrointestinal Ulceration.Gut and liver · 2016Review
- ML418: The First Selective, Sub-Micromolar Pore Blocker of Kir7.1 Potassium Channels.ACS chemical neuroscience · 2016Article
- The expression, regulation, and function of Kir4.1 (Kcnj10) in the mammalian kidney.American journal of physiology. Renal physiology · 2016Review
- Kir1.1 (ROMK) and Kv7.1 (KCNQ1/KvLQT1) are essential for normal gastric acid secretion: importance of functional Kir1.1.Pflugers Archiv : European journal of physiology · 2015Article
- Molecular aspects of structure, gating, and physiology of pH-sensitive background K2P and Kir K+-transport channels.Physiological reviews · 2015Review
- Acid secretion-associated translocation of KCNJ15 in gastric parietal cells.American journal of physiology. Gastrointestinal and liver physiology · 2011Article
- Kir4.1 channel expression is essential for parietal cell control of acid secretion.The Journal of biological chemistry · 2011Article
- Genetic dissection reveals unexpected influence of beta subunits on KCNQ1 K+ channel polarized trafficking in vivo.FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2011Article
- A chemical genetics approach reveals H,K-ATPase-mediated membrane voltage is required for planarian head regeneration.Chemistry & biology · 2011Article
- Article
- KCNQ1 is the luminal K+ recycling channel during stimulation of gastric acid secretion.The Journal of physiology · 2009Article
- The gastric H,K ATPase as a drug target: past, present, and future.Journal of clinical gastroenterology · 2007Review
- Regulatory mechanism of "K+recycling" for Na +reabsorption in renal tubules.Clinical and experimental nephrology · 2007Review
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Authors and funding
7 authors at 4 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Hydrochloric acid (HCl) is produced in parietal cells of gastric epithelium by a H(+)-K(+) pump. Protons are secreted into the gastric lumen in exchange for K(+) by the action of the H(+)-K(+)-ATPase. Luminal K(+) is essential for the operation of the pump and is thought to be supplied by unidentified K(+) channels localized at the apical membrane of parietal cells. In this study, we showed that histamine- and carbachol-induced acid secretion from isolated parietal cells monitored by intracellular accumulation of aminopyrine was depressed by Ba(2+), an inhibitor of inwardly rectifying K(+) channels. Among members of the inwardly rectifying K(+) channel family, we found with reverse transcriptase-polymerase chain reaction analyses that Kir4.1, Kir4.2 and Kir7.1 were expressed in rat gastric mucosa. With immunohistochemical analyses, Kir4.1 was found to be expressed in gastric parietal cells and localized specifically at their apical membrane. The current flowing through Kir4.1 channel expressed in HEK293T cells was not affected by reduction of extracellular pH from 7.4 to 3. These results suggest that Kir4.1 may be involved in the K(+) recycling pathway in the apical membrane which is required for activation of the H(+)-K(+) pump in gastric parietal cells.
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