ArticleThe Journal of experimental medicine2002
Major T cell progenitor activity in bone marrow-derived spleen colonies.
Article in The Journal of experimental medicine, 2002. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
11 citing papers in PubMed, 33 citations in OpenAlex.
- Ever-evolving insights into the cellular and molecular drivers of lymphoid cell development.Experimental hematology · 2024Review
- Cells and signals of the leukemic microenvironment that support progression of T-cell acute lymphoblastic leukemia (T-ALL).Experimental & molecular medicine · 2024Review
- Notch signaling in hematopoietic cell transplantation and T cell alloimmunity.Blood reviews · 2013Review
- Signal integration and crosstalk during thymocyte migration and emigration.Nature reviews. Immunology · 2011Review
- Hematopoietic progenitor migration to the adult thymus.Annals of the New York Academy of Sciences · 2011Review
- From the cradle to the grave: activities of GATA-3 throughout T-cell development and differentiation.Immunological reviews · 2010Review
- Eliciting the T cell fate with Notch.Seminars in immunology · 2010Review
- The long road to the thymus: the generation, mobilization, and circulation of T-cell progenitors in mouse and man.Seminars in immunopathology · 2008Review
- Hierarchy of Notch-Delta interactions promoting T cell lineage commitment and maturation.The Journal of experimental medicine · 2007Article
- Notch-dependent T-lineage commitment occurs at extrathymic sites following bone marrow transplantation.Blood · 2006Article
- Prethymic T-cell development defined by the expression of paired immunoglobulin-like receptors.The EMBO journal · 2005Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Common lymphoid progenitors (CLP) are generated in adult bone marrow (BM), but the intermediate steps leading to T cell commitment are unknown, and so is the site at which this commitment occurs. Here, we show that colonies arising in the spleen 12 days after BM injection harbor T cell precursors that are undetectable in BM. These precursors did not generate myeloid cells in vivo but repopulated the thymus and the peripheral T cell compartment much faster than did CLP. Two lineage negative (Lin(-)) subpopulations were distinguished, namely CD44(+) Thy1(-) cells still capable of natural killer generation and transient low-level B cell generation, and T cell-restricted CD44(-) Thy1(+) cells. At a molecular level, frequency of CD3epsilon and preTalpha mRNA was very different in each subset. Furthermore, only the CD44(-) Thy1(+) subset have initiated rearrangements in the T cell receptor beta locus. Thus, this study identifies extramedullary T cell progenitors and will allow easy approach to T cell commitment studies.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.