ArticleThe Journal of experimental medicine2002
CD1d-restricted human natural killer T cells are highly susceptible to human immunodeficiency virus 1 infection.
Article in The Journal of experimental medicine, 2002. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 100 papers.
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The trial behind it
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Who cites it
100 citing papers in PubMed, 214 citations in OpenAlex.
- Technical advance. Measurement of iNKT cell responses at the single-cell level against rare HIV-1-infected dendritic cells in a mixed culture.Journal of leukocyte biology · 2013Trial
- Expansion of CD1d-restricted NKT cells in patients with primary HIV-1 infection treated with interleukin-2.Blood · 2006Trial
- Nonclassical MHC-I Molecules: Emerging Therapeutic Targets in Next-Generation Immunotherapy.MedComm · 2026Review
- Chemokine-chemokine receptor axis: Emerging immunotherapeutic paradigms for solid tumor microenvironment reprogramming.Chinese medical journal · 2026Review
- Expression of CD38 on resting peripheral iNKT cells defines an immature subpopulation with distinct functionality in humans.Immunology and cell biology · 2026Article
- Melanoma in people living with HIV: Immune landscape dynamics and the role of immuno- and antiviral therapies.Cancer metastasis reviews · 2024Review
- The surveillance of viral infections by the unconventional Type I NKT cell.Frontiers in immunology · 2024Review
- CD3Journal of neuroimmunology · 2023Article
- Immunomodulatory potential ofiScience · 2022Article
- CXCR6 expressing T cells: Functions and role in the control of tumors.Frontiers in immunology · 2022Review
- ORFV infection enhances CXCL16 secretion and causes oncolysis of lung cancer cells through immunogenic apoptosis.Frontiers in cellular and infection microbiology · 2022Article
- Preferential and persistent impact of acute HIV-1 infection on CD4Proceedings of the National Academy of Sciences of the United States of America · 2021Article
- Role of NKT Cells during Viral Infection and the Development of NKT Cell-Based Nanovaccines.Vaccines · 2021Review
- Type I Natural Killer T Cells as Key Regulators of the Immune Response to Infectious Diseases.Clinical microbiology reviews · 2021Review
- Invariant Natural Killer T-cell Dynamics in Human Immunodeficiency Virus-associated Tuberculosis.Clinical infectious diseases : an official publication of the Infectious Diseases Society of America · 2020Article
- Differential skewing of donor-unrestricted and γδ T cell repertoires in tuberculosis-infected human lungs.The Journal of clinical investigation · 2020Article
- Dendritic Cell Maturation Regulates TSPAN7 Function in HIV-1 Transfer to CD4Frontiers in cellular and infection microbiology · 2020Article
- Suppression of R5-type of HIV-1 in CD4Scientific reports · 2019Article
- Mucosal Immunity in HIV/SIV Infection: T Cells, B Cells and Beyond.Current immunology reviews · 2019Article
- Liver as a target of human immunodeficiency virus infection.World journal of gastroenterology · 2018Review
40 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors at 2 institutions in 1 country.
Funding
Abstract
Human natural killer (NK) T cells are unique T lymphocytes that express an invariant T cell receptor (TCR) Valpha24-Vbeta11 and have been implicated to play a role in various diseases. A subset of NKT cells express CD4 and hence are potential targets for human immunodeficiency virus (HIV)-1 infection. We demonstrate that both resting and activated human Valpha24(+) T cells express high levels of the HIV-1 coreceptors CCR5 and Bonzo (CXCR6), but low levels of CCR7, as compared with conventional T cells. Remarkably NKT cells activated with alpha-galactosylceramide (alpha-GalCer)-pulsed dendritic cells were profoundly more susceptible to infection with R5-tropic, but not X4-tropic, strains of HIV-1, compared with conventional CD4(+) T cells. Furthermore, resting CD4(+) NKT cells were also more susceptible to infection. After initial infection, HIV-1 rapidly replicated and depleted the CD4(+) subset of NKT cells. In addition, peripheral blood NKT cells were markedly and selectively depleted in HIV-1 infected individuals. Although the mechanisms of this decline are not clear, low numbers or absence of NKT cells may affect the course of HIV-1 infection. Taken together, our findings indicate that CD4(+) NKT cells are directly targeted by HIV-1 and may have a potential role during viral transmission and spread in vivo.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.