ArticleThe Journal of clinical investigation2002
The melanin-concentrating hormone receptor 1, a novel target of autoantibody responses in vitiligo.
Article in The Journal of clinical investigation, 2002. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 34 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
34 citing papers in PubMed, 117 citations in OpenAlex.
- Markers of Systemic Metabolic Dysfunction in Vitiligo and Their Potential Role in Disease Pathogenesis: A Narrative Review.Health science reports · 2026Article
- Chronic interferon signaling at baseline is associated with acquired resistance to immunotherapy in metastatic melanoma.Cell reports. Medicine · 2026Article
- Vitiligo as a Failure of Immune Resolution and Tissue Regeneration: From Stress Signals to Targeted Immune Modulation.Clinical reviews in allergy & immunology · 2026Review
- The small molecule ML233 is a direct inhibitor of tyrosinase function.Communications biology · 2025Article
- The small molecule ML233 is a direct inhibitor of tyrosinase function.bioRxiv : the preprint server for biology · 2025Article
- Vitiligo and insulin resistance as a component of metabolic syndrome: an analysis.Postepy dermatologii i alergologii · 2023Review
- The Efficacy and Psychoneuroimmunology Mechanism of Camouflage Combined With Psychotherapy in Vitiligo Treatment.Frontiers in medicine · 2022Article
- Amino acid sequence homology between thyroid autoantigens and central nervous system proteins: Implications for the steroid-responsive encephalopathy associated with autoimmune thyroiditis.Journal of clinical & translational endocrinology · 2021Article
- An in-depth analysis reveals two new genetic variants on 22q11.2 associated with vitiligo in the Chinese Han population.Molecular biology reports · 2021Article
- Genetic deciphering of the antagonistic activities of the melanin-concentrating hormone and melanocortin pathways in skin pigmentation.PLoS genetics · 2020Article
- Breeding history and candidate genes responsible for black skin of Xichuan black-bone chicken.BMC genomics · 2020Article
- Global downregulation of pigmentation-associated genes in human premature hair graying.Experimental and therapeutic medicine · 2019Article
- Vitiligo immune reconstitution inflammatory syndrome (IRIS)-An incidental finding in a tertiary teaching hospital in southeast Nigeria.JAAD case reports · 2018Article
- Increased Risk of Metabolic Syndrome in Patients with Vitiligo.Balkan medical journal · 2017Article
- Detection of auto antibodies and transplantation of cultured autologous melanocytes for the treatment of vitiligo.Experimental and therapeutic medicine · 2017Article
- Evolution, immunity and the emergence of brain superautoantigens.F1000Research · 2017Article
- Vitiligo and Autoimmune Thyroid Disorders.Frontiers in endocrinology · 2017Review
- Case reports: Oral vitiligo.British dental journal · 2015Article
- Highlights in pathogenesis of vitiligo.World journal of clinical cases · 2015Review
- Oxidative stress and immune system in vitiligo and thyroid diseases.Oxidative medicine and cellular longevity · 2015Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
8 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Vitiligo is a common depigmenting disorder resulting from the loss of melanocytes in the skin. The pathogenesis of the disease remains obscure, although autoimmune mechanisms are thought to be involved. Indeed, autoantibodies and autoreactive T lymphocytes that target melanocytes have been reported in some vitiligo patients. The objective of this study was to identify pigment cell antigens that are recognized by autoantibodies in vitiligo. Using IgG from vitiligo patients to screen a melanocyte cDNA phage-display library, we identified the melanin-concentrating hormone receptor 1 (MCHR1) as a novel autoantigen related to this disorder. Immunoreactivity against the receptor was demonstrated in vitiligo patient sera by using radiobinding assays. Among sera from healthy controls and from patients with autoimmune disease, none exhibited immunoreactivity to MCHR1, indicating a high disease specificity for Ab's against the receptor. Inhibition of MCH binding to its receptor by IgG from vitiligo patients was also shown.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.