ArticleThe Journal of cell biology2002
PECAM-1 (CD31) regulates a hydrogen peroxide-activated nonselective cation channel in endothelial cells.
Article in The Journal of cell biology, 2002. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
15 citing papers in PubMed, 46 citations in OpenAlex.
- The Role of Cellular Glutathione Redox Cycle and Glutathione in the Regulation of Ileum Contractility.International journal of molecular sciences · 2026Article
- Personalized risk predictor for acute cellular rejection in lung transplant using soluble CD31.Scientific reports · 2022Article
- Metabolic adaptations of cells at the vascular-immune interface during atherosclerosis.Molecular aspects of medicine · 2021Article
- Mechanotransduction and Uterine Blood Flow in Preeclampsia: The Role of Mechanosensing Piezo 1 Ion Channels.American journal of hypertension · 2020Review
- Kinetics and dissolution of intratracheally administered nickel oxide nanomaterials in rats.Particle and fibre toxicology · 2017Article
- Platelet Endothelial Cell Adhesion Molecule-1 and Oligodendrogenesis: Significance in Alcohol Use Disorders.Brain sciences · 2017Review
- Influence of PECAM-1 ligand interactions on PECAM-1-dependent cell motility and filopodia extension.Physiological reports · 2016Article
- CCL2 disrupts the adherens junction: implications for neuroinflammation.Laboratory investigation; a journal of technical methods and pathology · 2012Article
- Involvement of endothelial-derived relaxing factors in the regulation of cerebral blood flow.Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology · 2011Review
- Dynamic changes of platelet endothelial cell adhesion molecule-1 (PECAM-1/CD31) on pulmonary injury induced by ischemia-reperfusion in rats.Irish journal of medical science · 2011Article
- SHP-2 phosphatase activity is required for PECAM-1-dependent cell motility.American journal of physiology. Cell physiology · 2010Article
- Regulation of trophoblast beta1-integrin expression by contact with endothelial cells.Cell communication and signaling : CCS · 2004Article
- Platelet endothelial cell adhesion molecule in cell signaling and thrombosis.Molecular and cellular biochemistry · 2003Review
- Endothelium dysfunction in LDL receptor knockout mice: a role for H2O2.British journal of pharmacology · 2003Article
- Evidence for a role of platelet endothelial cell adhesion molecule-1 in endothelial cell mechanosignal transduction: is it a mechanoresponsive molecule?The Journal of cell biology · 2002Article
Corrections and comments
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Authors and funding
8 authors at 3 institutions in 1 country.
Funding
Abstract
Hydrogen peroxide (H2O2) released by neutrophils is an important mediator of endothelial cell (EC) injury and vascular inflammation via its effect on EC-free Ca2+, [Ca2+]i. Although the underlying mechanisms are not well understood, platelet endothelial cell adhesion molecule (PECAM)-1/CD-31 is a critical modulator of neutrophil-EC transmigration. PECAM-1 is also known to regulate EC calcium signals and to undergo selective tyrosine phosphorylation. Here, we report that PECAM-1 molecules transduce EC responses to hydrogen peroxide. In human umbilical vein EC and REN cells (a PECAM-1-negative EC-like cell line) stably transfected with PECAM-1 (RHP), noncytolytic H2O2 exposure (100-200 microM H2O2) activated a calcium-permeant, nonselective cation current, and a transient rise in [Ca2+]i of similar time course. Neither response was observed in untransfected REN cells, and H2O2-evoked cation current was ablated in REN cells transfected with PECAM-1 constructs mutated in the cytoplasmic tyrosine-containing domain. The PECAM-dependent H2O2 current was inhibited by dialysis of anti-PECAM-1 cytoplasmic domain antibodies, required Src family tyrosine kinase activity, was independent of inositol trisphosphate receptor activation, and required only an intact PECAM-1 cytoplasmic domain. PECAM-1-dependent H2O2 currents and associated [Ca2+]i transients may play a significant role in regulating neutrophil-endothelial interaction, as well as in oxidant-mediated endothelial response and injury.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.