ReviewSeminars in cancer biology2002
Assumptions of the tumor 'escape' hypothesis.
Review in Seminars in cancer biology, 2002. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
13 citing papers in PubMed.
- Combination of external beam radiotherapy (EBRT) with intratumoral injection of dendritic cells as neo-adjuvant treatment of high-risk soft tissue sarcoma patients.International journal of radiation oncology, biology, physics · 2012Trial
- Risk factors for complications after cytoreductive surgery (CRS) and HIPEC in 290 peritoneal malignancies of primary and secondary origins.Updates in surgery · 2026Article
- T cells are blind to the dark mechanics of tumors.Trends open · 2026Review
- A Holistic Perspective: Exosomes Shuttle between Nerves and Immune Cells in the Tumor Microenvironment.Journal of clinical medicine · 2020Review
- Combined treatment of murine fibrosarcoma with chemotherapy (Paclitaxel), radiotherapy, and intratumoral injection of dendritic cells.Annals of dermatology · 2014Article
- Serial assessment of lymphocytes and apoptosis in the prostate during coordinated intraprostatic dendritic cell injection and radiotherapy.Immunotherapy · 2012Article
- The confluence of stereotactic ablative radiotherapy and tumor immunology.Clinical & developmental immunology · 2011Review
- Photodynamic therapy of tumors can lead to development of systemic antigen-specific immune response.PloS one · 2010Article
- Tissue- and tumor-specific targeting of murine leukemia virus-based replication-competent retroviral vectors.Journal of virology · 2006Article
- Immunotherapy for malignant gliomas: emphasis on strategies of active specific immunotherapy using autologous dendritic cells.Child's nervous system : ChNS : official journal of the International Society for Pediatric Neurosurgery · 2005Review
- The selection of tumor variants with altered expression of classical and nonclassical MHC class I molecules: implications for tumor immune escape.Cancer immunology, immunotherapy : CII · 2004Review
- Immunotherapy of cancer for the elderly patient: does allogeneic bone marrow transplantation after nonmyeloablative conditioning provide a new option?Cancer immunology, immunotherapy : CII · 2004Review
- Natural selection of tumor variants in the generation of "tumor escape" phenotypes.Nature immunology · 2002Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors.
Funding
Abstract
The reasons why cancer cells are not destroyed by the immune system are likely to be similar, in most cases, to the reasons why normal cells are not destroyed by the immune system. Unfortunately for tumor immunologists, these reasons have not yet been fully elucidated. What is known, however, is that the lack of autoimmune destruction of normal tissue after immune activation is a finely regulated, highly orchestrated sequence of events. Viewed in this light, it is interesting to conceptualize the derangement of the tumor genome not merely as an engine that enables cancer cells to dodge immune recognition. The dysregulation characteristic of the transformed genome is also what makes tumor immunity, a specialized form of autoimmunity, possible.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.