ArticleWorld journal of gastroenterology2002
Effect of areca on contraction of colonic muscle strips in rats.
Article in World journal of gastroenterology, 2002. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.
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Who cites it
5 citing papers in PubMed.
- Effects of Chinese herbal medicine Xiangbin prescription on gastrointestinal motility.World journal of gastroenterology · 2017Trial
- Effects of neurotrophins on gastrointestinal myoelectric activities of rats.World journal of gastroenterology · 2003Article
- Action of progesterone on contractile activity of isolated gastric strips in rats.World journal of gastroenterology · 2003Article
- Effect of pinaverium bromide on stress-induced colonic smooth muscle contractility disorder in rats.World journal of gastroenterology · 2003Article
- Effect of oxytocin on contraction of rabbit proximal colon in vitro.World journal of gastroenterology · 2003Article
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Authors and funding
8 authors.
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No grant is acknowledged in the PubMed record.
Abstract
aimTo investigate the effects of areca on the contractile activity of isolated colonic muscle strips in rats and mechanism involved.
methodsEach strip (LMPC, longitudinal muscle of proximal colon; CMPC, circular muscle of proximal colon; LMDC, longitudinal muscle of distal colon; CMDC, circular muscle of distal colon.) was suspended in a tissue chamber containing 5 mL Krebs solution (37 degrees C), bubbled continuously with 950 mL.L(-1) O(2) and 50 mL.L(-1) CO(2). The mean contractile amplitude (A), the resting tension (T), and the contractile frequency (F) were simultaneously recorded on recorders.
resultsAreca dose dependently increased the mean contractile amplitude, the resting tension of proximal and distal colonic smooth muscle strips in rats (P<0.05). It also partly increased the contractile frequency of colonic smooth muscle strips in rats (P<0.05). The effects were partly inhibited by atropine (the resting tension of LMPC decreased from 0.44 +/- 0.12 to 0.17 +/- 0.03; the resting tension of LMDC decreased from 0.71 +/- 0.14 to 0.03 +/- 0.01; the mean contractile amplitude of LMPC increased from -45.8 +/- 7.2 to -30.5 +/- 2.9; the motility index of CMDC decreased from 86.6 +/- 17.3 to 32.8 +/- 9.3; P<0.05 vs areca), but the effects were not inhibited by hexamethonium (P>0.05).
conclusionAreca stimulated the motility of isolated colonic smooth muscle strips in rats. The stimulation of areca might be relevant with M receptor partly.
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