ArticleWorld journal of gastroenterology2002
Nuclear factor kB activity in patients with acute severe cholangitis.
Article in World journal of gastroenterology, 2002. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
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Who cites it
18 citing papers in PubMed, 25 citations in OpenAlex.
- Proportion of Neutrophils in White Blood Cells as a Useful Marker for Predicting Bacteremic Acute Cholangitis.Internal medicine (Tokyo, Japan) · 2023Article
- Expression of scavenger receptor A in rat's liver tissue during acute obstructive cholangitis and its significance.SpringerPlus · 2016Article
- Role of high-mobility group box 1 in patients with acute obstructive suppurative cholangitis-induced sepsis.Journal of inflammation research · 2015Article
- Effect of malaria components on blood mononuclear cells involved in immune response.Asian Pacific journal of tropical biomedicine · 2013Review
- Magnolol attenuates sepsis-induced gastrointestinal dysmotility in rats by modulating inflammatory mediators.World journal of gastroenterology · 2008Article
- Effects of IkappaBalpha and its mutants on NF-kappaB and p53 signaling pathways.World journal of gastroenterology · 2006Article
- Nuclear factor-kappaB decoy oligodeoxynucleotides attenuates ischemia/reperfusion injury in rat liver graft.World journal of gastroenterology · 2005Article
- Effect of resveratrol on activation of nuclear factor kappa-B and inflammatory factors in rat model of acute pancreatitis.World journal of gastroenterology · 2005Article
- Ketamine suppresses intestinal NF-kappa B activation and proinflammatory cytokine in endotoxic rats.World journal of gastroenterology · 2004Article
- Expression of NF-kappaB and human telomerase reverse transcriptase in gastric cancer and precancerous lesions.World journal of gastroenterology · 2004Article
- Effect of NF-kappaB, survivin, Bcl-2 and Caspase3 on apoptosis of gastric cancer cells induced by tumor necrosis factor related apoptosis inducing ligand.World journal of gastroenterology · 2004Article
- Role of NF-kappaB and cytokine in experimental cancer cachexia.World journal of gastroenterology · 2003Article
- Immunotolerance of liver allotransplantation induced by intrathymic inoculation of donor soluble liver specific antigen.World journal of gastroenterology · 2003Article
- Synthesis of endotoxin receptor CD14 protein in Kupffer cells and its role in alcohol-induced liver disease.World journal of gastroenterology · 2003Article
- Role of NF-kB in multiple organ dysfunction during acute obstructive cholangitis.World journal of gastroenterology · 2003Article
- Intestinal damage mediated by Kupffer cells in rats with endotoxemia.World journal of gastroenterology · 2002Article
- Expression of CD14 protein and its gene in liver sinusoidal endothelial cells during endotoxemia.World journal of gastroenterology · 2002Article
- Liver sinusoidal endothelial cell injury by neutrophils in rats with acute obstructive cholangitis.World journal of gastroenterology · 2002Article
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Authors and funding
6 authors at 4 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
aimTo determine the NF-kB activity in peripheral blood mononuclear cells (PBMC) in patients with acute cholangitis of severe type (ACST) and correlate the degree of NF-kB activation with severity of biliary tract infection and clinical outcome.
methodsTwenty patients with ACST were divided into survivor group (13 cases) and nonsurvivor group (7 cases). Other ten patients undergoing elective gastrectomy or inguinal hernia repair were selected as control group. Peripheral blood samples were taken 24 hours postoperatively. PBMC were separated by density gradient centrifugation, then nuclear proteins were isolated from PBMC, and Electrophoretic Mobility Shift Assay (EMSA) used determined. The results were quantified by scanning densitometer of a Bio-Image Analysis System and expressed as relative optical density (ROD). The levels of TNF-alpha, IL-6, and IL-10 in the plasma of patients with ACST and healthy control subjects were determined by using an enzyme-linked immunoassay (ELISA).
resultsThe NF-kB activity was 5.02 +/- 1.03 in nonsurvivor group, 2.98 +/- 0.51 in survivor group and 1.06 +/- 0.34 in control group. There were statistical differences in three groups (P<0.05). The levels of TNF-alpha and IL-6 in plasma were (498 +/- 53)ng.L(-1)and (587 +/- 64)ng.L(-1)in nonsurvivor group, (284 +/- 32)ng.L(-1) and (318 +/- 49)ng.L(-1)in survivor group and (89 +/- 11)ng.L(-1) and (102 +/-13)ng.L(-1)in control group. All patients with ACST had increased levels of TNF-alpha and IL-6, which were many-fold greater than those of control group, and there was an evidence of significantly higher levels in those of nonsurvivor group than that in survivor group (P<0.05). The levels of IL-10 in plasma were (378+/-32)ng.L(-1), (384+/-37)ng.L(-1) and (68+/-11)ng.L(-1) in three groups, respectively. All patients had also increased levels of IL-10 when compared with control group (P<0.05), but the IL-10 levels were not significantly higher in nonsurvivors than in survivors (P>0.05).
conclusionNF-kB activity in PBMC in patients with ACST increases markedly and the degree of NF-kB activation is correlated with severity of biliary tract infection and clinical outcome.
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