ArticleWorld journal of gastroenterology2002
Effects of progesterone on gastric emptying and intestinal transit in male rats.
Article in World journal of gastroenterology, 2002. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
26 citing papers in PubMed, 59 citations in OpenAlex.
- Sex hormones and functional gastrointestinal disorders in menopausal women.Frontiers in endocrinology · 2026Review
- Nausea and Gastric Myoelectrical Activity Are Influenced by Hormonal Contraception in Chronic Gastroduodenal Disorders.Clinical and translational gastroenterology · 2025Article
- Preoperative gastric retention in endoscopic retrograde cholangiopancreatography.World journal of gastrointestinal surgery · 2024Article
- Impact of Physiological Fluctuations of Sex Hormones During the Menstrual Cycle on Glucose Metabolism and the Gut Microbiota.Experimental and clinical endocrinology & diabetes : official journal, German Society of Endocrinology [and] German Diabetes Association · 2024Review
- Physical and psychological correlates of somatic symptom in patients with functional constipation: a cross-sectional study.BMC psychiatry · 2024Article
- Dietary energy intake across the menstrual cycle: a narrative review.Nutrition reviews · 2023Review
- Mechanism of Oxytocin-Induced Contraction in Rat Gastric Circular Smooth Muscle.International journal of molecular sciences · 2022Article
- Progesterone inhibitory role on gastrointestinal motility.Physiological research · 2022Review
- The intestine and the microbiota in maternal glucose homeostasis during pregnancy.The Journal of endocrinology · 2022Review
- The differences in intestinal growth and microorganisms between male and female ducks.Poultry science · 2021Article
- Supplementation of 17β-Estradiol Normalizes Rapid Gastric Emptying by Restoring Impaired Nrf2 and nNOS Function in Obesity-Induced Diabetic Ovariectomized Mice.Antioxidants (Basel, Switzerland) · 2020Article
- Evolution, the Menstrual Cycle, and Theoretical Overreach.Perspectives on psychological science : a journal of the Association for Psychological Science · 2020Article
- The influence of demographic characteristics on constipation symptoms: a detailed overview.BMC gastroenterology · 2020Article
- The role of oxytocin in regulation of appetitive behaviour, body weight and glucose homeostasis.Journal of neuroendocrinology · 2020Review
- Effect of progesterone on nitric oxide/cyclic guanosine monophosphate signaling and contraction in gastric smooth muscle cells.Biomedical reports · 2018Article
- Differential regulation of intestinal efflux transporters by pregnancy in mice.Xenobiotica; the fate of foreign compounds in biological systems · 2017Article
- Role of sex hormones in gastrointestinal motility in pregnant and non-pregnant rats.World journal of gastroenterology · 2016Article
- Symptomatology of irritable bowel syndrome and inflammatory bowel disease during the menstrual cycle.Gastroenterology report · 2015Review
- Gender-related differences in irritable bowel syndrome: potential mechanisms of sex hormones.World journal of gastroenterology · 2014Review
- Interaction among hormones or peptides may be involved in gastric motor physiology.Journal of neurogastroenterology and motility · 2012Article
Corrections and comments
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Authors and funding
5 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
aimTo study the dose-dependent of progesterone (P) effect and the interaction between the oxytocin (OT) and P on gastrointestinal motility.
methodsIn order to monitor the gastric emptying and intestinal transit, the SD male rats were intubated via a catheter with normal saline (3 ml/kg) containing Na(2)(51)CrO(4) (0.5 microCi/ml) and 10% charcoal. OT was dissolved into normal saline and P was dissolved into 75% alcohol.
resultsLow does of P (1 mg/kg, i.p.) enhanced the gastric emptying (75+/-3%, P<0.05) and high dose of P (5 mg/kg, i.p.) inhibit it (42+/-11.2%, P<0.01). P (1 mg/kg) increased the intestinal transit (4.2+/-0.3, P<0.05) while the higher dose (10-20 mg/kg) had no effect. OT (0.8 mg/kg, i.p.) inhibited the gastric emptying (23.5+/-9.8%, P<0.01). The inhibitory effects of P(20 mg/kg) (32+/-9.7%, P<0.05) and OT (0.8 mg/kg) on gastric emptying enhanced each other when the two chemicals were administrated simultaneously (17+/-9.4%, P<0.01).
conclusionLow dose of P increased GI motility while high dose of P decreased it. During the later period of pregnancy, elevated plasma level of OT may also participate in the gastrointestinal inhibition.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.