ArticleAmerican journal of human genetics2002
A genomewide linkage scan for quantitative-trait loci for obesity phenotypes.
Article in American journal of human genetics, 2002. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 65 papers, 3 of them syntheses that pooled it.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
65 citing papers in PubMed, 3 syntheses or guidelines pooled it, 159 citations in OpenAlex.
- Replication of FTO Gene associated with lean mass in a Meta-Analysis of Genome-Wide Association Studies.Scientific reports · 2020Pooled it
- Identification of shared genetic susceptibility locus for coronary artery disease, type 2 diabetes and obesity: a meta-analysis of genome-wide studies.Cardiovascular diabetology · 2012Pooled it
- Genome-wide association and replication studies identified TRHR as an important gene for lean body mass.American journal of human genetics · 2009Pooled it
- Chromosomal regions strongly associated with waist circumference and body mass index in metabolic syndrome in a family-based study.Scientific reports · 2021Trial
- Circadian Gene Variants: Effects in Overweight and Obese Pregnant Women.International journal of molecular sciences · 2024Article
- Association between CLOCK gene polymorphisms with circadian rhythm, chrononutrition, dietary intake, and metabolic parameters in adolescents.Frontiers in public health · 2024Article
- Association of 3p27.1 Variants with Whole Body Lean Mass Identified by a Genome-wide Association Study.Scientific reports · 2020Article
- Differentially conserved transcriptomic response to adversity related to self-rated health in the multi-ethnic study of atherosclerosis.Experimental biology and medicine (Maywood, N.J.) · 2017Article
- Association between SNPs and haplotypes in the METTL21C gene and peak bone mineral density and body composition in Chinese male nuclear families.Journal of bone and mineral metabolism · 2017Article
- Circadian CLOCK gene polymorphisms in relation to sleep patterns and obesity in African Americans: findings from the Jackson heart study.BMC genetics · 2017Article
- Gene-based genome-wide association study identified 19p13.3 for lean body mass.Scientific reports · 2017Article
- SNP-SNP interactions between WNT4 and WNT5A were associated with obesity related traits in Han Chinese Population.Scientific reports · 2017Article
- The role of neuromedin U in adiposity regulation. Haplotype analysis in European children from the IDEFICS Cohort.PloS one · 2017Article
- Epigenomic elements analyses for promoters identify ESRRG as a new susceptibility gene for obesity-related traits.International journal of obesity (2005) · 2016Article
- Controversial association results for INSIG2 on body mass index may be explained by interactions with age and with MC4R.European journal of human genetics : EJHG · 2014Article
- Genome wide association study: searching for genes underlying body mass index in the Chinese.Biomedical and environmental sciences : BES · 2014Article
- Genome-wide association study identified copy number variants important for appendicular lean mass.PloS one · 2014Article
- From obesity genetics to the future of personalized obesity therapy.Nature reviews. Endocrinology · 2013Review
- Ethnic differentiation of copy number variation on chromosome 16p12.3 for association with obesity phenotypes in European and Chinese populations.International journal of obesity (2005) · 2013Article
- Article
5 more citing papers are in PubMed but not listed here.
Corrections and comments
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Authors and funding
11 authors at 2 institutions in 2 countries.
Funding
Abstract
Obesity is an increasingly serious health problem in the world. Body mass index (BMI), percentage fat mass, and body fat mass are important indices of obesity. For a sample of pedigrees that contains >10,000 relative pairs (including 1,249 sib pairs) that are useful for linkage analyses, we performed a whole-genome linkage scan, using 380 microsatellite markers to identify genomic regions that may contain quantitative-trait loci (QTLs) for obesity. Each pedigree was ascertained through a proband who has extremely low bone mass, which translates into a low BMI. A major QTL for BMI was identified on 2q14 near the marker D2S347 with a LOD score of 4.04 in two-point analysis and a maximum LOD score (MLS) of 4.44 in multipoint analysis. The genomic region near 2q14 also achieved an MLS >2.0 for percentage of fat mass and body fat mass. For the putative QTL on 2q14, as much as 28.2% of BMI variation (after adjustment for age and sex) may be attributable to this locus. In addition, several other genomic regions that may contain obesity-related QTLs are suggested. For example, 1p36 near the marker D1S468 may contain a QTL for BMI variation, with a LOD score of 2.75 in two-point analysis and an MLS of 2.09 in multipoint analysis. The genomic regions identified in this and earlier reports are compared for further exploration in extension studies that use larger samples and/or denser markers for confirmation and fine-mapping studies, to eventually identify major functional genes involved in obesity.
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