ArticleThe Journal of neuroscience : the official journal of the Society for Neuroscience2002
Target interaction regulates distribution and stability of specific mRNAs.
Article in The Journal of neuroscience : the official journal of the Society for Neuroscience, 2002. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
What it found
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Who cites it
20 citing papers in PubMed, 33 citations in OpenAlex.
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- Intra-axonal protein synthesis in development and beyond.International journal of developmental neuroscience : the official journal of the International Society for Developmental Neuroscience · 2016Review
- cJun and CREB2 in the postsynaptic neuron contribute to persistent long-term facilitation at a behaviorally relevant synapse.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2015Article
- Asymmetric localization of natural antisense RNA of neuropeptide sensorin in Aplysia sensory neurons during aging and activity.Frontiers in genetics · 2014Article
- Axonal mRNA localization and local protein synthesis in nervous system assembly, maintenance and repair.Nature reviews. Neuroscience · 2012Review
- Persistent long-term synaptic plasticity requires activation of a new signaling pathway by additional stimuli.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2011Article
- The nonsense-mediated decay pathway maintains synapse architecture and synaptic vesicle cycle efficacy.Journal of cell science · 2010Article
- Aplysia cell adhesion molecule and a novel protein kinase C activity in the postsynaptic neuron are required for presynaptic growth and initial formation of specific synapses.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2010Article
- Subcellular mRNA localization in animal cells and why it matters.Science (New York, N.Y.) · 2009Review
- Multifunctional role of protein kinase C in regulating the formation and maturation of specific synapses.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2007Article
- Protein kinase C regulates local synthesis and secretion of a neuropeptide required for activity-dependent long-term synaptic plasticity.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2007Article
- Two mRNA-binding proteins regulate the distribution of syntaxin mRNA in Aplysia sensory neurons.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2006Article
- Two signaling pathways regulate the expression and secretion of a neuropeptide required for long-term facilitation in Aplysia.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2006Article
- Pyrene binary probes for unambiguous detection of mRNA using time-resolved fluorescence spectroscopy.Nucleic acids research · 2006Article
- Target-dependent release of a presynaptic neuropeptide regulates the formation and maturation of specific synapses in Aplysia.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2004Article
- The two regulatory subunits of aplysia cAMP-dependent protein kinase mediate distinct functions in producing synaptic plasticity.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2004Article
- RNA translation in axons.Annual review of cell and developmental biology · 2004Review
- Stimulus-dependent translocation of egg-laying hormone encoding mRNA into the axonal compartment of the neuroendocrine caudodorsal cells.Invertebrate neuroscience : IN · 2003Article
- Redistribution of syntaxin mRNA in neuronal cell bodies regulates protein expression and transport during synapse formation and long-term synaptic plasticity.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2003Article
- Local translation of mRNAs in neural development.Wiley interdisciplinary reviews. RNAReview
Corrections and comments
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Authors and funding
3 authors at 2 institutions in 1 country.
Funding
Abstract
Several factors regulate export of mRNAs from neuronal cell bodies. Using in situ hybridization and RT-PCR, we examined how target interaction influences the distribution of mRNAs expressed in sensory neurons (SNs) of Aplysia maintained in cell culture. Interaction with a synaptic target has two effects on the distribution of mRNA encoding an SN-specific peptide, sensorin: the target affects the accumulation of sensorin mRNA at the axon hillock and the stability of sensorin mRNA exported to distal sites. Synapse formation with motor neuron L7 results in the accumulation of high levels of sensorin mRNA in the axon hillock of the SN and in SN neurites contacting L7. SNs cultured alone or in contact with motor neuron L11, with which no synapses form, show a more uniform distribution of sensorin mRNA in the cytoplasm of the SN cell body, with little expression in neurites. Contact with L7 or L11 had little or no effect on the distribution of two other mRNAs in the cytoplasm of SN cell bodies. Sensorin mRNA exported to SN neurites after 1 d in culture is more stable when the SN contacts L7 compared with SN neurites that contact L11. After removal of the SN cell body, the amounts of sensorin mRNA already exported to the neurites are greater when neurites contact L7 compared with neurites in contact with L11. The results indicate that target interaction and synapse formation regulate both the accumulations of specific mRNAs destined for export and their stability at distant sites.
Indexed as
Identifiers
11923432PMC6758340W1516410787What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.