ArticleThe Journal of neuroscience : the official journal of the Society for Neuroscience2002
Cell density and N-cadherin interactions regulate cell proliferation in the sensory epithelia of the inner ear.
Article in The Journal of neuroscience : the official journal of the Society for Neuroscience, 2002. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
27 citing papers in PubMed, 72 citations in OpenAlex.
- An essential signaling cascade for avian auditory hair cell regeneration.Developmental cell · 2024Article
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- Paraquat initially damages cochlear support cells leading to anoikis-like hair cell death.Hearing research · 2018Article
- A model for cell migration in non-isotropic fibrin networks with an application to pancreatic tumor islets.Biomechanics and modeling in mechanobiology · 2018Article
- ADAM10 and γ-secretase regulate sensory regeneration in the avian vestibular organs.Developmental biology · 2017Article
- Cisplatin exposure damages resident stem cells of the mammalian inner ear.Developmental dynamics : an official publication of the American Association of Anatomists · 2014Article
- Postnatal development, maturation and aging in the mouse cochlea and their effects on hair cell regeneration.Hearing research · 2013Review
- Anatomical expression patterns of delta-protocadherins in developing chicken cochlea.Journal of anatomy · 2012Article
- Concise review: Inner ear stem cells--an oxymoron, but why?Stem cells (Dayton, Ohio) · 2012Review
- An RNA interference-based screen of transcription factor genes identifies pathways necessary for sensory regeneration in the avian inner ear.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2011Article
- Variations in shape-sensitive restriction points mirror differences in the regeneration capacities of avian and mammalian ears.PloS one · 2011Article
- Cisplatin ototoxicity blocks sensory regeneration in the avian inner ear.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2010Article
- Downstream targets of GATA3 in the vestibular sensory organs of the inner ear.Developmental dynamics : an official publication of the American Association of Anatomists · 2009Article
- Local cell metrics: a novel method for analysis of cell-cell interactions.BMC bioinformatics · 2009Article
- Epigenetic influences on sensory regeneration: histone deacetylases regulate supporting cell proliferation in the avian utricle.Journal of the Association for Research in Otolaryngology : JARO · 2009Article
- Cell proliferation follows acoustically-induced hair cell bundle loss in the zebrafish saccule.Hearing research · 2009Article
- Notch regulation of progenitor cell behavior in quiescent and regenerating auditory epithelium of mature birds.Developmental biology · 2009Article
- Reinforcement of cell junctions correlates with the absence of hair cell regeneration in mammals and its occurrence in birds.The Journal of comparative neurology · 2008Article
- Peptide- and collagen-based hydrogel substrates for in vitro culture of chick cochleae.Biomaterials · 2008Article
- Closure of supporting cell scar formations requires dynamic actin mechanisms.Hearing research · 2007Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
1 author at 1 institution in 1 country.
Funding
Abstract
Sensory hair cells in the inner ears of nonmammalian vertebrates can regenerate after injury. In many species, replacement hair cells are produced by the proliferation of epithelial supporting cells. Thus, the ability of supporting cells to undergo renewed proliferation is a key determinant of regenerative ability. The present study used cultures of isolated inner ear sensory epithelia to identify cellular signals that regulate supporting cell proliferation. Small pieces of sensory epithelia from the chicken utricle were cultured in glass microwells. Under those conditions, cell proliferation was inversely related to local cell density. The signaling molecules N-cadherin, beta-catenin, and focal adhesion kinase were immunolocalized in the cultured epithelial cells, and high levels of phosphotyrosine immunoreactivity were present at cell-cell junctions and focal contacts of proliferating cells. Binding of microbeads coated with a function-blocking antibody to N-cadherin inhibited ongoing proliferation. The growth of epithelial cells was also affected by the density of extracellular matrix molecules. The results suggest that cell density, cell-cell contact, and the composition of the extracellular matrix may be critical influences on the regulation of sensory regeneration in the inner ear.
Indexed as
Identifiers
11923426PMC6758293W1748298985What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.