ArticleThe Journal of neuroscience : the official journal of the Society for Neuroscience2002
Failure of brain-derived neurotrophic factor-dependent neuron survival in mouse trisomy 16.
Article in The Journal of neuroscience : the official journal of the Society for Neuroscience, 2002. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 22 papers, 1 of them a synthesis that pooled it.
What it found
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
22 citing papers in PubMed, 1 synthesis or guideline pooled it.
- TrkB Truncated Isoform Receptors as Transducers and Determinants of BDNF Functions.Frontiers in neuroscience · 2022Pooled it
- Regulation of NTRK2 alternative splicing by PRPF40B controls neural differentiation and synaptic plasticity.Cell death & disease · 2025Article
- Alzheimer's therapeutic development: shifting neurodegeneration to neuroregeneration.Trends in pharmacological sciences · 2024Review
- Neuroinflammation as the Underlying Mechanism of Postoperative Cognitive Dysfunction and Therapeutic Strategies.Frontiers in cellular neuroscience · 2022Review
- Astrocytic BDNF and TrkB regulate severity and neuronal activity in mouse models of temporal lobe epilepsy.Cell death & disease · 2020Article
- Dysregulation of BDNF/TrkB signaling mediated by NMDAR/CaJournal of neuroinflammation · 2020Article
- Deletion of the endogenous TrkB.T1 receptor isoform restores the number of hippocampal CA1 parvalbumin-positive neurons and rescues long-term potentiation in pre-symptomatic mSOD1(G93A) ALS mice.Molecular and cellular neurosciences · 2018Article
- Truncated TrkB.T1-Mediated Astrocyte Dysfunction Contributes to Impaired Motor Function and Neuropathic Pain after Spinal Cord Injury.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2017Article
- Restrained Phosphatidylcholine Synthesis in a Cellular Model of Down's Syndrome is Associated with the Overexpression of Dyrk1A.Molecular neurobiology · 2017Article
- Increased cortical synaptic activation of TrkB and downstream signaling markers in a mouse model of Down Syndrome.Neurobiology of disease · 2015Article
- Transection of preganglionic axons leads to CNS neuronal plasticity followed by survival and target reinnervation.Autonomic neuroscience : basic & clinical · 2013Article
- TrkB.T1 contributes to neuropathic pain after spinal cord injury through regulation of cell cycle pathways.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2013Article
- BDNF regulates the expression and distribution of vesicular glutamate transporters in cultured hippocampal neurons.PloS one · 2013Article
- Stimulation of the neurotrophin receptor TrkB on astrocytes drives nitric oxide production and neurodegeneration.The Journal of experimental medicine · 2012Article
- Imbalance of neurotrophin receptor isoforms TrkB-FL/TrkB-T1 induces neuronal death in excitotoxicity.Cell death & disease · 2012Article
- Genetic deletion of trkB.T1 increases neuromuscular function.American journal of physiology. Cell physiology · 2012Article
- TrkB Isoforms Differentially Affect AICD Production through Their Intracellular Functional Domains.International journal of Alzheimer's disease · 2011Article
- In vivo evidence that truncated trkB.T1 participates in nociception.Molecular pain · 2009Article
- Interleukin-1 beta impairs brain derived neurotrophic factor-induced signal transduction.Neurobiology of aging · 2008Article
- Nucleotide sequence variation within the human tyrosine kinase B neurotrophin receptor gene: association with antisocial alcohol dependence.The pharmacogenomics journal · 2007Article
Corrections and comments
- Erratum issued
Authors and funding
4 authors.
Funding
Abstract
The neurotrophin, brain derived neurotrophic factor (BDNF), exerts multiple effects on the development and maintenance of the nervous system, including regulating synaptic plasticity and promoting neuron survival. Here we report the selective failure of BDNF-dependent survival in cultured hippocampal neurons from the trisomy 16 (Ts16) mouse, an animal model of Down syndrome. This failure is accompanied by overexpression of a truncated, kinase-deficient isoform (T1) of the BDNF receptor tyrosine receptor kinase B (trkB). Adenovirus-mediated introduction of exogenous full-length trkB into Ts16 neurons fully restored BDNF-dependent survival, whereas exogenous truncated trkB expression in normal, euploid neurons reproduced the Ts16 BDNF signaling failure. Thus, the failure of Ts16 neurons to respond to BDNF is caused by dysregulation of trkB isoform expression. Such a neurotrophin signaling defect could contribute to developmental and degenerative disorders of the nervous system.
Indexed as
Identifiers
11923422PMC6758291What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.