ArticleThe Journal of neuroscience : the official journal of the Society for Neuroscience2002
Specificity of glomerular targeting by olfactory sensory axons.
Article in The Journal of neuroscience : the official journal of the Society for Neuroscience, 2002. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 83 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
83 citing papers in PubMed, 196 citations in OpenAlex.
- The Role of Olfaction in Dogs: Evolution, Biology, and Human-Oriented Work.Animals : an open access journal from MDPI · 2026Review
- Major bioactive metabolites derived fromFrontiers in pharmacology · 2026Review
- Glomeruli of the Mouse Olfactory Bulb: Numbers, Sizes, Shapes.The European journal of neuroscience · 2025Article
- Olfactory Development and Dysfunction: Involvement of Microglia.Physiology (Bethesda, Md.) · 2025Review
- Visualizing the human olfactory projection and ancillary structures in a 3D reconstruction.Communications biology · 2024Article
- Common principles for odour coding across vertebrates and invertebrates.Nature reviews. Neuroscience · 2024Review
- Integrated age-related immunohistological changes occur in human olfactory epithelium and olfactory bulb.The Journal of comparative neurology · 2022Article
- Developing and maintaining a nose-to-brain map of odorant identity.Open biology · 2022Review
- Severe histomorphological alterations in post-mortem olfactory glomeruli in Alzheimer's disease.Brain pathology (Zurich, Switzerland) · 2022Article
- Development of the mammalian main olfactory bulb.Development (Cambridge, England) · 2022Review
- Experimental and theoretical probe on mechano- and chemosensory integration in the insect antennal lobe.Frontiers in physiology · 2022Article
- Maximal Dependence Capturing as a Principle of Sensory Processing.Frontiers in computational neuroscience · 2022Article
- The role of the odorant receptors in the formation of the sensory map.BMC biology · 2021Review
- Phagocytosis by Peripheral Glia: Importance for Nervous System Functions and Implications in Injury and Disease.Frontiers in cell and developmental biology · 2021Review
- Olfactory Dysfunction in Huntington's Disease.Journal of Huntington's disease · 2021Review
- Article
- Modulation of the combinatorial code of odorant receptor response patterns in odorant mixtures.Molecular and cellular neurosciences · 2020Article
- Article
- P/Q Type Calcium Channel Cav2.1 Defines a Unique Subset of Glomeruli in the Mouse Olfactory Bulb.Frontiers in cellular neuroscience · 2018Article
- A ventral glomerular deficit in Parkinson's disease revealed by whole olfactory bulb reconstruction.Brain : a journal of neurology · 2017Article
23 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 2 institutions in 1 country.
Funding
Abstract
Axons from olfactory sensory neurons (OSNs) expressing a specific odorant receptor (OR) project to specific subsets of glomeruli in the olfactory bulb (for review, see Mombaerts, 1999, 2001). The aim of this study was to examine the trajectories that subsets of axons from OSNs expressing the same OR follow within the olfactory nerve and olfactory nerve layer (ONL) of adult mice. Using confocal microscopy, we generated serial reconstructions of axons from M72-IRES-tauGFP-expressing OSNs as they coursed within the ONL and into glomeruli. GFP-expressing axons were loosely aggregated in the outer ONL; however, as they entered the inner ONL, the majority fasciculated with other GFP-expressing axons before entering the glomerular neuropil. Although the vast majority of axons entered the glomerulus from the directly apposed ONL, some followed tortuous courses through and/or around adjacent glomeruli before terminating in the target glomerulus. Similar observations were made on subpopulations of axons in M71-IRES-tauGFP and P2-IRES-tauGFP mice. Ultrastructural analyses of labeled M72 glomeruli showed no evidence of axodendritic synapses other than those with GFP-labeled axon terminals. These data are consistent with the notion that OSN axons are highly precise in targeting glomeruli and that glomeruli, in turn, are highly homogeneous with regard to the OR expressed by the innervating OSNs. Because some single axons could follow idiosyncratic trajectories to the target glomerulus, it appears that stable homotypic fasciculation is not a prerequisite for correct targeting.
Indexed as
Identifiers
11923411PMC6758332W1740677000What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.