ArticleThe Journal of neuroscience : the official journal of the Society for Neuroscience2002
Rapid neuromodulatory actions of integrin ligands.
Article in The Journal of neuroscience : the official journal of the Society for Neuroscience, 2002. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
16 citing papers in PubMed, 1 synthesis or guideline pooled it, 51 citations in OpenAlex.
- Cell adhesion and intracellular calcium signaling in neurons.Cell communication and signaling : CCS · 2013Pooled it
- Pharmacological Tools to Activate Microglia and their Possible use to Study Neural Network Patho-physiology.Current neuropharmacology · 2017Review
- Dopamine increases NMDA-stimulated calcium flux in striatopallidal neurons through a matrix metalloproteinase-dependent mechanism.The European journal of neuroscience · 2016Article
- Activity dependent CAM cleavage and neurotransmission.Frontiers in cellular neuroscience · 2015Review
- Localization of αvβ3-like integrin in cultivated larval cells of the mussel Mytilus trossulus during neuronal and muscle differentiation.Journal of molecular histology · 2012Article
- Transcriptome analysis of the central nervous system of the mollusc Lymnaea stagnalis.BMC genomics · 2009Article
- Activity-dependent regulation of synaptic AMPA receptor composition and abundance by beta3 integrins.Neuron · 2008Article
- Integrin regulation of cytoplasmic calcium in excitatory neurons depends upon glutamate receptors and release from intracellular stores.Molecular and cellular neurosciences · 2008Article
- Interaction of transient receptor potential vanilloid 4, integrin, and SRC tyrosine kinase in mechanical hyperalgesia.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2008Article
- Integrins regulate opioid receptor signaling in trigeminal ganglion neurons.Neuroscience · 2007Article
- Tissue inhibitor of metalloproteinase-2 (TIMP-2) expression is regulated by multiple neural differentiation signals.Journal of neurochemistry · 2006Article
- Beta 1-integrins are required for hippocampal AMPA receptor-dependent synaptic transmission, synaptic plasticity, and working memory.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2006Article
- Regulation of the hyperpolarization-activated cationic current Ih in mouse hippocampal pyramidal neurones by vitronectin, a component of extracellular matrix.The Journal of physiology · 2004Article
- Regulation of an inactivating potassium current (IA) by the extracellular matrix protein vitronectin in embryonic mouse hippocampal neurones.The Journal of physiology · 2003Article
- Do apoptotic mechanisms regulate synaptic plasticity and growth-cone motility?Neuromolecular medicine · 2002Review
- A potential role for integrin signaling in mechanoelectrical feedback.Progress in biophysics and molecular biologyReview
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Extracellular matrix (ECM) proteins and their receptors, the integrins, actively participate in the control of many fundamental cellular functions in the developing nervous system, including the regulation of cell migration, differentiation, and survival and the control of neurite outgrowth. ECM-integrin interactions in the mature nervous system are commonly considered to be more static in nature and of little importance in the regulation of neuronal function. In contrast, we demonstrate that integrins and their ligands are capable of rapid neuromodulatory actions. Specifically, we show that integrin ligands can alter neuronal pacemaker properties, intracellular free Ca2+ levels, and voltage-gated Ca2+ currents in a matter of minutes. These findings indicate that ECM-integrin interactions play a dynamic role in regulating the physiological status of mature neurons, a process that may contribute to synaptic plasticity, neural regeneration, and neuropathology.
Indexed as
Identifiers
11923405PMC6758314W2130391111What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.