ArticleJournal of clinical microbiology2002
Laccase and melanization in clinically important Cryptococcus species other than Cryptococcus neoformans.
Article in Journal of clinical microbiology, 2002. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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Who cites it
14 citing papers in PubMed, 76 citations in OpenAlex.
- Papiliotrema laurentii: general features and biotechnological applications.Applied microbiology and biotechnology · 2022Review
- Dihydroxynaphthalene-Based Allomelanins: A Source of Inspiration for Innovative Technological Materials.ACS omega · 2022Review
- Article
- Comparison of clinical and biological characteristics of HIV-infected patients presenting Cryptococcus neoformans versus C. curvatus/C. laurentii meningitis.BMC infectious diseases · 2021Article
- Comparison ofFrontiers in cellular and infection microbiology · 2021Article
- Soil Yeast Communities in Revegetated Post-Mining and Adjacent Native Areas in Central Brazil.Microorganisms · 2020Article
- Antifungal susceptibility, enzymatic activity, PCR-fingerprinting and ITS sequencing of environmental Cryptococcus laurentii isolates from Uberaba, Minas Gerais, Brazil.Mycopathologia · 2012Article
- Cryptococcus spp isolated from dust microhabitat in Brazilian libraries.Journal of occupational medicine and toxicology (London, England) · 2012Article
- Ptilomycalin A inhibits laccase and melanization in Cryptococcus neoformans.Bioorganic & medicinal chemistry · 2011Article
- Evaluation of the experimental inoculation of Cryptococcus albidus and Cryptococcus laurentii in normal mice: virulence factors and molecular profile before and after animal passage.Mycopathologia · 2009Article
- Synthesis of cell envelope glycoproteins of Cryptococcus laurentii.Carbohydrate research · 2007Review
- Isolation of Cryptococcus laurentii from Canada Goose guano in rural upstate New York.Mycopathologia · 2006Article
- Dual infections with pigmented and albino strains of Cryptococcus neoformans in patients with or without human immunodeficiency virus infection in India.Journal of clinical microbiology · 2005Article
- Cryptococcus neoformans resistance to echinocandins: (1,3)beta-glucan synthase activity is sensitive to echinocandins.Antimicrobial agents and chemotherapy · 2005Article
Corrections and comments
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Authors and funding
4 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The laccase enzyme and melanin synthesis have been implicated as contributors to virulence in Cryptococcus neoformans. Since isolations of Cryptococcus species other than C. neoformans from clinical specimens have been increasing, we examined the laccase activities of C. albidus, C. laurentii, C. curvatus, and C. humicola. Incubation of cells with epinephrine produced adrenochrome color in C. albidus, C. laurentii, and C. curvatus but not in C. humicola. Activity was always less than in C. neoformans. Laccase was detected in the soluble fractions of disrupted C. albidus, C. laurentii, and C. curvatus cells. Activity staining of partially purified enzyme after nondenaturing polyacrylamide gel electrophoresis revealed that laccases from C. albidus, C. laurentii, and C. curvatus migrated more slowly than that from C. neoformans. One strain of C. curvatus exhibited two melanin bands. Thus, several clinically emerging Cryptococcus species express laccase and can synthesize melanin.
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