ArticleJournal of clinical microbiology2002
Population structure and genetic diversity of Actinobacillus actinomycetemcomitans strains isolated from localized juvenile periodontitis patients.
Article in Journal of clinical microbiology, 2002. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 52 papers, 2 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
52 citing papers in PubMed, 2 syntheses or guidelines pooled it, 119 citations in OpenAlex.
- Association between periodontitis and dental caries: a systematic review and meta-analysis.Clinical oral investigations · 2024Pooled it
- Prevalence of the JP2 genotype of Aggregatibacter actinomycetemcomitans in the world population: a systematic review.Clinical oral investigations · 2022Pooled it
- Distribution of nicotinamide phosphoribosyltransferase in genusFrontiers in microbiology · 2026Article
- Serotype Distribution ofPathogens (Basel, Switzerland) · 2025Article
- Occurrence ofMicroorganisms · 2024Article
- Article
- Discrepancies in Antimicrobial Susceptibility between the JP2 and the Non-JP2 Genotype ofAntibiotics (Basel, Switzerland) · 2022Article
- Multilocus Sequence Typing of Aggregatibacter actinomycetemcomitans Competently Depicts the Population Structure of the Species.Microbiology spectrum · 2021Article
- Oleoresins and naturally occurring compounds of Copaifera genus as antibacterial and antivirulence agents against periodontal pathogens.Scientific reports · 2021Article
- Grade C molar-incisor pattern periodontitis subgingival microbial profile before and after treatment.Journal of oral microbiology · 2020Article
- Whole Genome Sequencing ofPathogens (Basel, Switzerland) · 2019Article
- Review
- Dental caries are positively associated with periodontal disease severity.Clinical oral investigations · 2019Article
- Aggregatibacter (Actinobacillus) actimycetemcomitans leukotoxin and human periodontitis - A historic review with emphasis on JP2.The Kaohsiung journal of medical sciences · 2018Review
- Accuracy of commercial kits and published primer pairs for the detection of periodontopathogens.Clinical oral investigations · 2016Article
- Characterization of A. actinomycetemcomitans strains in subgingival samples from periodontitis subjects in Morocco.Clinical oral investigations · 2016Article
- Occurrence and serotype distribution of Aggregatibacter actinomycetemcomitans in subjects without periodontitis in Turkey.Archives of oral biology · 2016Article
- Mature Biofilm Degradation by Potential Probiotics: Aggregatibacter actinomycetemcomitans versus Lactobacillus spp.PloS one · 2016Article
- Microbial protection and virulence in periodontal tissue as a function of polymicrobial communities: symbiosis and dysbiosis.Periodontology 2000 · 2015Review
- Prevalence and distribution of Aggregatibacter actinomycetemcomitans and its cdtB gene in subgingival plaque of Chinese periodontitis patients.BMC oral health · 2014Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The phylogeny of 20 Actinobacillus actinomycetemcomitans strains isolated from patients with localized juvenile periodontitis (LJP) was investigated by using partial sequence analysis of 16S rRNA genes, arbitrarily primed PCR (AP-PCR), and four additional PCR assays that amplified polymorphic regions in the leukotoxin (lkt), cytolethal distending toxin (cdt), major fimbrial subunit (flp-1), and serotype-specific O polysaccharide gene clusters. Our analysis also included four strains isolated from healthy subjects and nine reference strains. We found that A. actinomycetemcomitans strains comprised three major phylogenetic lineages. One lineage consisted of serotype b strains, a second lineage consisted of serotype c strains, and a third lineage consisted of serotype a, d, e, and f strains. 16S rRNA sequences within each lineage were highly conserved (<1% base substitutions), whereas sequences between lineages were exceptionally divergent (1.9 to 5.0% substitutions). Two strains exhibited 16S rRNA sequences that were even more distantly related to those of the three major lineages (2.7 to 6.7% substitutions), indicating that additional minor lineages or variants exist. The distribution of 16S rRNA sequences and lkt, cdt, flp-1, and AP-PCR genotypes was consistent with a clonal population structure, with little evidence of assortative recombination between strains of different serotypes. Strains from all three major lineages were recovered from LJP patients, suggesting that phylogenetically diverse strains of A. actinomycetemcomitans carry pathogenic potential.
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