ArticleNeoplasia (New York, N.Y.)
Stable karyotypes in epithelial cancer cell lines despite high rates of ongoing structural and numerical chromosomal instability.
Article in Neoplasia (New York, N.Y.). The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 46 papers.
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Who cites it
46 citing papers in PubMed.
- Mitotic BLM functions are required to maintain genomic stability.Nucleic acids research · 2026Article
- Chromosome 20q gene signature associated with colorectal cancer progression.Oncology reports · 2025Article
- Challenges in the preclinical design and assessment of CAR-T cells.Frontiers in immunology · 2025Review
- The reckoning of chromosomal instability: past, present, future.Chromosome research : an international journal on the molecular, supramolecular and evolutionary aspects of chromosome biology · 2024Review
- Characterisation of cell lines derived from prostate cancer patients with localised disease.Prostate cancer and prostatic diseases · 2023Article
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- Identification of a signature of evolutionarily conserved stress-induced mutagenesis in cancer.Frontiers in genetics · 2022Article
- Genome-Wide CRISPR Screening to Identify Mammalian Factors that Regulate Intron Retention.Methods in molecular biology (Clifton, N.J.) · 2022Article
- Imaging Unique DNA Sequences in Individual Cells Using a CRISPR-Cas9-Based, Split Luciferase Biosensor.Frontiers in genome editing · 2022Article
- Reverting to single-cell biology: The predictions of the atavism theory of cancer.Progress in biophysics and molecular biology · 2021Article
- Depletion of Trichoplein (TpMs) Causes Chromosome Mis-Segregation, DNA Damage and Chromosome Instability in Cancer Cells.Cancers · 2020Article
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- Reinvestigation of Disulfide-bonded Oligomeric Forms of the Unfolded Protein Response Transducer ATF6.Cell structure and function · 2020Article
- Intellectual disability-associated gain-of-function mutations in CERT1 that encodes the ceramide transport protein CERT.PloS one · 2020Article
- Updated summary of genome editing technology in human cultured cells linked to human genetics studies.Journal of human genetics · 2018Review
- DNA damage in dental pulp mesenchymal stem cells: AnVeterinary research forum : an international quarterly journal · 2018Article
- Human MLH1 suppresses the insertion of telomeric sequences at intra-chromosomal sites in telomerase-expressing cells.Nucleic acids research · 2017Article
- Living in CIN: Mitotic Infidelity and Its Consequences for Tumor Promotion and Suppression.Developmental cell · 2016Review
- High rates of chromosome missegregation suppress tumor progression but do not inhibit tumor initiation.Molecular biology of the cell · 2016Article
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5 authors.
Funding
Abstract
Most human tumors and tumor cell lines exhibit numerical and structural chromosomal abnormalities. The goal of this study was to determine the ongoing rates of structural and numerical instability in selected cancer cell lines and to investigate the consequences of these rates to karyotypic progression. We studied two colorectal (HCT-116 and HT-29) and two ovarian (SKOV-3 and OVCAR-8) cancer cell lines and their single cell subclones. We found that the signature karyotypes of all four cell lines were distinct and each aberrant. Whereas high rates of ongoing structural and/ or numerical chromosomal instability could be demonstrated in all cell lines, there was a relative stability of the consensus karyotype over many generations. No new clonal structural chromosomal reconfigurations emerged and the few numerical changes of karyotypes were restricted to abnormal chromosomes. This implies a kind of genomic optimization under the conditions of cell culture and suggests a link between genomic stabilization and cell propagation. We have been able to support this possibility by computer modeling. We did not observe a profound difference in the rates of numerical or structural instability in the cell lines with a replication error phenotype (RER+) versus the other cell lines.
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