ArticleMammalian genome : official journal of the International Mammalian Genome Society2002
Genome-wide search for markers associated with bovine spongiform encephalopathy.
Article in Mammalian genome : official journal of the International Mammalian Genome Society, 2002. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
12 citing papers in PubMed, 27 citations in OpenAlex.
- Association mapping of genetic risk factors for chronic wasting disease in wild deer.Evolutionary applications · 2013Article
- Functional genomics approach for identification of molecular processes underlying neurodegenerative disorders in prion diseases.Current genomics · 2012Article
- PRNP and SPRN genes polymorphism in atypical bovine spongiform encephalopathy cases diagnosed in Polish cattle.Journal of applied genetics · 2012Article
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- Identification of new quantitative trait Loci (other than the PRNP gene) modulating the scrapie incubation period in sheep.Genetics · 2008Article
- PRNP promoter polymorphisms are associated with BSE susceptibility in Swiss and German cattle.BMC genetics · 2007Article
- Mapping of multiple quantitative trait loci affecting bovine spongiform encephalopathy.Genetics · 2004Article
- Prion gene sequence variation within diverse groups of U.S. sheep, beef cattle, and deer.Mammalian genome : official journal of the International Mammalian Genome Society · 2003Article
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Corrections and comments
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
A genome-wide search for markers associated with BSE incidence was performed by using Transmission-Disequilibrium Tests (TDTs). Significant segregation distortion, i.e., unequal transmission probabilities of alleles within a locus, was found for three marker loci on Chromosomes (Chrs) 5, 10, and 20. Although TDTs are robust to false associations owing to hidden population substructures, it cannot distinguish segregation distortion caused by a true association between a marker and bovine spongiform encephalopathy (BSE) from a population-wide distortion. An interaction test and a segregation distortion analysis in half-sib controls were used to disentangle these two alternative hypotheses. None of the markers showed any significant interaction between allele transmission rates and disease status, and only the marker on Chr 10 showed a significant segregation distortion in control individuals. Nevertheless, the control group may have been a mixture of resistant and susceptible but unchallenged individuals. When new genotypes were generated in the vicinity of these three markers, evidence for an association with BSE was confirmed for the locus on Chr 5.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.